Actovegin 40 mg / ml 10 ml 5 pcs.

1 ampoule contains:

active substance:

 Actovegin® concentrate (in terms of dry deproteinized hemoderivative of calf blood) 1) - 400.0 mg;

 
excipient:

water for injection - up to 10 ml.

1) The Actovegin® concentrate contains sodium chloride in the form of sodium and chlorine ions, which are components of the blood of calves. Sodium chloride is not added or removed during the concentrate production process.

The sodium chloride content is about 53.6 mg (for 2 ml ampoules), about 134.0 mg (for 5 ml ampoules) and about 268.0 mg (for 10 ml ampoules).

Actovegin has a positive effect on the transport and utilization of glucose, stimulates oxygen consumption (which leads to stabilization of the plasma membranes of cells during ischemia and a decrease in the formation of lactates), thus having an antihypoxic effect, which begins to manifest itself at the latest 30 minutes (10-30 minutes) after parenteral administration and reaches a maximum and average after 3 hours (2-6 hours).

Actovegin increases the concentration of ATP, LDF, phosphocreatine, as well as amino acids - glutamate, aspartate and GABA.

The use of the drug Actovegin to accelerate wound healing is also based on the data mentioned above. At the same time, not only morphological, but also biochemical parameters of granulations improve - the concentration of DNA increases. hemoglobin and hydroxyproline.

•  metabolic and vascular disorders of the brain (including ischemic stroke, traumatic brain injury);
•  wound healing (ulcers of various etiologies, burns, trophic disorders (bedsores), impaired wound healing processes);
•  prevention and treatment of radiation injuries of the skin and mucous membranes during radiation therapy.
•  peripheral (arterial and venous) vascular disorders and their consequences (arterial angiopathy, trophic ulcers);

•  hypersensitivity to Actovegin® or similar drugs;
•  decompensated heart failure;
•  pulmonary edema;
•  oliguria, anuria;
•  fluid retention in the body.
• With care: hyperchloremia, hypernatremia.

Allergic reactions (skin rash, skin flushing, hyperthermia) up to anaphylactic shock.

It is currently unknown.

Intravenous, intravenous (including as an infusion) and intramuscularly. Due to the potential for anaphylactic reactions, it is recommended that a test be performed before starting the infusion.

Depending on the severity of the clinical picture, 10-20 ml / day IV or IV; then 5 ml i / v or 5 ml i / m.

When administered in the form of an infusion, 10-20 ml of Actovegin® is added to 200-300 ml of the stock solution (0.9% sodium chloride solution or 5% dextrose solution). Injection rate: about 2 ml / min.

Metabolic and vascular disorders of the brain: at the beginning of treatment, 10 ml intravenously daily for two weeks, then 5-10 ml intravenously 3-4 times a week for at least 2 weeks.

Ischemic stroke: 20-50 ml in 200-300 ml of the main solution IV drip daily for 1 week, then 10-20 ml IV drip for 2 weeks.

Peripheral (arterial and venous) vascular disorders and their consequences: 20-30 ml of the drug in 200 ml of the main solution i / a or i / v daily; the duration of treatment is about 4 weeks.

Wound healing: 10 ml IV or 5 ml IM daily or 3-4 times a week, depending on the healing process (in addition to local treatment with Actovegin® in topical dosage forms).

Prevention and treatment of radiation injuries of the skin and mucous membranes during radiation therapy: the average dose is 5 ml / in daily during the intervals of radiation exposure.

Radiation cystitis: 10 ml daily transurethral in combination with antibiotic therapy.

Due to the possibility of an anaphylactic reaction, it is recommended to carry out a trial injection (2 ml intramuscularly).

Solution for injection has a slightly yellowish tint. The color intensity may vary from one batch to another depending on the characteristics of the starting materials used, but this does not adversely affect the activity of the drug or its tolerance.

In the case of intramuscular administration, no more than 5 ml is injected slowly.

Do not use a cloudy solution or solution containing particles. After opening the ampoule, the solution cannot be stored.

Solution for injection is clear, yellowish, practically free of particles.