Product Overview
Structure
Active substance - acyclovir 5 g
Excipients - nipazole.
nipagin,
Cremophor A6.
Cremophor A25.
cetyl alcohol
propylene glycol
petroleum jelly,
purified water.
pharmachologic effect
Acyclovir is active against Herpes simplex types 1 and 2, Varicella zoster virus, Epstein Barr virus and cytomegaloviruses.
The thymidine kinase of virus-infected cells activates acyclovir into acyclovir mono-, di- and triphosphate through a series of sequential reactions.
The latter interacts with viral DNA polymerase and integrates into DNA, which is synthesized for new viruses. Thus, defective viral DNA is formed, which leads to suppression of replication of new generations of viruses.
Pharmacokinetics:
Indications
Infections of the skin and mucous membranes caused by the Herpes simplex virus types 1 and 2, genital herpes, herpes zoster, chickenpox.
Pregnancy and lactation
Adequate and well-controlled clinical trials of the safety of the drug during pregnancy have not been conducted.
Use is indicated only in cases where the intended benefit to the mother outweighs the potential risk to the fetus.
During the treatment period, it is necessary to decide on the termination of breastfeeding.
Contraindications
Hypersensitivity to acyclovir and other components of the drug.
With caution - pregnancy, lactation, dehydration, renal failure.
With caution - pregnancy, lactation, dehydration, renal failure.
Side effects
Hyperemia, dryness, peeling of the skin; burning, inflammation in contact with mucous membranes.
Perhaps the development of allergic dermatitis.
Interaction
With external use, no interaction with other drugs was detected.
How to take, course of administration and dosage
Outwardly. The drug is applied 5 times a day (every 4 hours) with a thin layer on the affected and adjacent skin areas.
The cream is applied either with a cotton swab or with clean hands to avoid additional infection of the affected areas.
Therapy should be continued until the crust forms on the vesicles, or until they completely heal.
The duration of therapy is an average of 5 days and should not exceed 10 days.
Special instructions
To achieve the maximum therapeutic effect, it is necessary to start using the drug as soon as possible after the onset of infection (at the first signs of the disease: burning, itching, tingling, sensation of tension and redness).
The cream is not recommended to be applied to the mucous membranes of the mouth and eyes, as the development of severe local inflammation is possible.
In the treatment of genital herpes, sexual contact or condoms should be avoided, since the use of acyclovir does not prevent the transmission of the virus to partners.
Release form
5% cream for external use in aluminum tubes of 3, 5, 10 g.
Together with the instructions for use, they are placed in a pack of cardboard.
Storage conditions
List B. At a temperature of 12 to 15 ° C.
Keep out of the reach of children.
Shelf life
2 years.
