Product Overview
Composition
1 g of cream contains:
Active ingredient:
sulfathiazole silver salt 20 mg.
Basis: up to 1 g.
Base components:
liquid paraffin;
cetostearyl alcohol;
petrolatum;
sodium lauryl sulfate;
glycerol;
propyl hydroxybenzoate;
methylhydroxybenzoate;
potassium hydrogen phosphate;
sodium dihydrogen phosphate;
water for injections.
pharmachologic effect
The drug with antibacterial action for external use. Promotes healing of wounds (burns, trophic, purulent), provides effective protection of wounds from infection, reduces the time of treatment and preparation of the wound for skin transplantation, in many cases leads to an improvement in the condition, eliminating the need for transplantation
The sulfanilamide, silver sulfathiazole, which is part of the cream, is an antimicrobial bacteriostatic agent, has a wide spectrum of antibacterial action against gram-positive and gram-negative bacteria.
The mechanism of the antimicrobial action of sulfathiazole - inhibition of the growth and reproduction of microbes - is associated with competitive antagonism with para-aminobenzoic acid and inhibition of dihydropteroate synthetase, which leads to disruption of the synthesis of dihydrofolic acid and, ultimately, its active metabolite, tetrahydrofolic acid, and purimine microscopic acid, which is necessary for the synthesis ...
The silver ions present in the preparation enhance the antibacterial effect of sulfanilamide - they inhibit the growth and division of bacteria by binding with deoxyribonucleic acid of a microbial cell. In addition, silver ions weaken the sensitizing properties of sulfanilamidanilamide. Due to minimal resorption, the drug has no toxic effect.
The sulfanilamide, silver sulfathiazole, which is part of the cream, is an antimicrobial bacteriostatic agent, has a wide spectrum of antibacterial action against gram-positive and gram-negative bacteria.
The mechanism of the antimicrobial action of sulfathiazole - inhibition of the growth and reproduction of microbes - is associated with competitive antagonism with para-aminobenzoic acid and inhibition of dihydropteroate synthetase, which leads to disruption of the synthesis of dihydrofolic acid and, ultimately, its active metabolite, tetrahydrofolic acid, and purimine microscopic acid, which is necessary for the synthesis ...
The silver ions present in the preparation enhance the antibacterial effect of sulfanilamide - they inhibit the growth and division of bacteria by binding with deoxyribonucleic acid of a microbial cell. In addition, silver ions weaken the sensitizing properties of sulfanilamidanilamide. Due to minimal resorption, the drug has no toxic effect.
Indications
- Burns of all degrees of any etiology (including thermal, solar, chemical, electric shock, radiation); frostbite;
- purulent wounds;
- minor household injuries (cuts, abrasions);
- infected dermatitis, simple contact dermatitis, impetigo, microbial eczema, streptostaphyloderma;
- bedsores;
- trophic ulcers of the leg of various origins (including in chronic venous insufficiency, obliterating endarteritis, angiopathies in diabetes mellitus, erysipelas).
Contraindications
- Hypersensitivity (including to other sulfonamides).
- Congenital deficiency of glucose-6-phosphate dehydrogenase.
- Early childhood (newborns and infants up to 2 months, premature babies) due to the risk of developing nuclear jaundice.
- Not recommended for use during pregnancy.
- During breastfeeding, the drug can be prescribed only if the burn surface does not exceed 20% of the body surface, and the therapeutic benefit for the mother is greater than the possible risk for the child.
Side effects
Skin and allergic reactions.
Sometimes irritation is possible, manifested by a burning sensation at the site of application of the cream.
With prolonged use, blood changes characteristic of systemic sulfonamides (eg leukopenia), desquamative dermatitis may develop.
Interaction
It is not recommended to use it together with other local medicines.
Folic acid and its structural analogs (eg procaine) are capable of weakening the antimicrobial effect of sulfathiazole.
How to take, course of administration and dosage
The drug is applied topically both by the open method and in the form of occlusive dressings. After cleansing and surgical treatment, in compliance with the conditions of sterility, the preparation is applied to the wound with a layer 2-3 mm thick 2-3 times / day.
The wound should be covered with cream during treatment. If part of the wound opens, additional cream should be applied. The cream is applied until the wound is completely healed or until the time of skin grafting.
If exudate appears as a result of applying the cream to infected wounds, the wound should be washed with a 0.1% aqueous solution of chlorhexidine or other antiseptic before reapplying the cream.
The maximum daily dose is 25 g. The maximum duration of treatment is 60 days.
Overdose
Overdose cases have not been registered.
Special instructions
In hepatic and / or renal insufficiency, the serum sulfathiazole concentration should be monitored. Care should be taken to prescribe the drug to patients in a state of shock, with extensive burns due to the impossibility of collecting a full allergic anamnesis.
The drug does not limit the psychophysical ability, the ability to drive vehicles and maintain machinery in motion.
Influence on the ability to drive vehicles and use mechanisms
Release form
Cream.
Storage conditions
At a temperature not exceeding 25 ° C (do not freeze).
Keep out of the reach of children.
Shelf life
2 years.