Asparkam Renewal 24 pcs

Asparkam is a source of potassium and magnesium ions, regulates metabolic processes, helps to restore electrolyte balance, and has an antiarrhythmic effect.

The potassium ion is involved in both the conduction of impulses along the nerve fibers, and in synaptic transmission, the implementation of muscle contractions, and the maintenance of normal cardiac activity. Disruption of the exchange of potassium ions leads to a change in the excitability of nerves and muscles. 

Active ion transport maintains a high gradient of potassium ions across the plasma membrane. In small doses, the potassium ion dilates the coronary arteries, in large doses it narrows. It has a negative chrono- and batmotropic effect, in high doses - negative ino- and dromotropic, as well as a moderate diuretic effect.

The magnesium ion is a cofactor for 300 enzymatic reactions. An indispensable element in the processes that ensure the supply and consumption of energy. Participates in the balance of electrolytes, transport of ions, membrane permeability, neuromuscular excitability. 

It is included in the structure (pentose phosphate) of deoxyribonucleic acid. Participates in the synthesis of ribonucleic acid, the apparatus of heredity, cell growth, in the process of cell division. Limits and prevents excessive release of catecholamine during stress, lipolysis and release of free fatty acids are possible. It is a "physiological" blocker of slow calcium channels. Promotes the penetration of potassium ion into cells.

Asparaginate promotes the penetration of potassium and magnesium ions into the intracellular space, stimulates the intercellular synthesis of phosphates.

Pharmacokinetics

Hypersensitivity to the drug, metabolic disorders of amino acids, arterial hypotension, acute and chronic renal failure, hyperkalemia, hypermagnesemia, atrioventricular conduction disorder (atrioventricular block I-III degree), severe myasthenia gravis, hemolysis, adrenal insufficiency, age up to 18 years security not established).

It is prescribed with caution during pregnancy and during breastfeeding, lactation.

Pharmacodynamic: combined use with potassium-sparing diuretics (triamterene, spironolactone), beta-blockers, cyclosporine, heparin, angiotensin-converting enzyme inhibitors, nonsteroidal anti-inflammatory drugs increases the risk of hyperkalemia up to the development of arrhythmia and asystole. The use of potassium preparations in conjunction with glucocorticosteroids eliminates the hypokalemia caused by the latter.

Due to the content of potassium ions, the undesirable effects of cardiac glycosides are reduced.

Due to the content of magnesium ions, it reduces the effect of neomycin, polymyxin B, tetracycline and streptomycin.

With simultaneous use, the drug can enhance the neuromuscular blockade caused by depolarizing muscle relaxants (atracuria besylate, decametonium bromide, suxamethonium (chloride, bromide, iodide)).

Calcitriol increases the content of magnesium ions in blood plasma; calcium preparations reduce the effect of magnesium preparations.

Symptoms: impaired conduction (especially with previous pathology of the cardiac conduction system).

In case of cardiac arrhythmias in combination with atrioventricular block, it is not recommended to use Asparkam.

Information about the possible effect of the medicinal product for medical use on the ability to drive vehicles, mechanisms

At a temperature not higher than 25 ° C.