Product Overview
pharmachologic effect
Nootropic drug. Citicoline, being a precursor of key ultrastructural components of the cell membrane (mainly phospholipids), has a wide spectrum of action: it promotes the restoration of damaged cell membranes, inhibits the action of phospholipases, preventing the excessive formation of free radicals, and also prevents cell death by affecting the mechanisms of apoptosis.
In the acute period of stroke, it reduces the volume of damaged tissue and improves cholinergic transmission.
In case of traumatic brain injury, it reduces the duration of post-traumatic coma and the severity of neurological symptoms.
Citicoline improves the symptoms observed during hypoxia: memory impairment, emotional lability, lack of initiative, difficulties in performing daily activities and self-care. Effective in the treatment of cognitive, sensory and motor neurological disorders of degenerative and vascular etiology.
Pharmacokinetics
Since citicoline is a naturally occurring compound found in the body, a classic pharmacokinetic study cannot be performed due to the difficulty in quantifying exogenous and endogenous citicoline.
Indications of the active substances of the drug Citicoline
Dosage regimen
When taken orally - 200-300 mg 3 times a day.
IV for strokes and traumatic brain injury in the acute period - 1-2 g/day, depending on the severity of the disease, for 3-7 days, followed by switching to IM administration or oral administration.
V/m - 0.5-1 g/day.
Side effect
From the nervous system: insomnia, headache, dizziness, agitation, tremor, numbness in paralyzed limbs.
From the digestive system: nausea, loss of appetite, changes in the activity of liver enzymes.
Allergic reactions: rash, itchy skin, anaphylactic shock.
Other: fever; in some cases - short-term hypotensive effect, stimulation of the parasympathetic nervous system.
Contraindications for use
Vagotonia (predominance of the tone of the parasympathetic part of the autonomic nervous system); children and adolescents up to 18 years of age; hypersensitivity to citicoline.
Use during pregnancy and breastfeeding
During pregnancy, use is possible only if the expected benefit of therapy for the mother outweighs the potential risk to the fetus.
If it is necessary to use citicoline during lactation, the issue of stopping breastfeeding should be decided, since there is no data on the excretion of citicoline in breast milk.
Use in children
Contraindicated in children and adolescents under 18 years of age.
Use in elderly patients
special instructions
Drug interactions
Citicoline enhances the effects of L-dihydroxyphenylalanine.