Cytoflavin

1 tablet contains:

active substances:

succinic acid - 0.3 g;

riboxin (inosine) - 0.05 g;

nicotinamide - 0.025 g;

riboflavin mononucleotide (riboflavin) - 0.005 g;

Excipients:

polyvinylpyrrolidone medium molecular weight (povidone),

calcium stearate

copolymer of methacrylic acid and ethyl acrylate,

1,2 – propylene glycol,

acid red 2C,

Tropeolin O.

Pharmacodynamics

Pharmacological effects are due to the complex effect of the components included in the composition of the drug CYTOFLAVIN®.
CYTOFLAVIN® promotes the activation of aerobic metabolism of cells, which leads to an increase in glucose utilization, contributes to an increased level of beta-oxidation of fatty acids and the resynthesis of γ-aminobutyric acid in neurons.

CYTOFLAVIN® increases the resistance of the membranes of nerve and glial cells to the effects of ischemia, which is reflected in a decrease in the concentration of neurospecific proteins that characterize the level of destruction of the main structural components of the nervous tissue.
CYTOFLAVIN® improves coronary and cerebral blood flow, activates metabolic processes in the central nervous system, restores impaired consciousness, helps to regress neurological symptoms and improve cognitive functions of the brain. It has a quick awakening effect in post-anesthetic depression of consciousness.

When using the drug CYTOFLAVIN® in the first 12 hours from the onset of stroke, a favorable course of ischemic and necrotic processes in the affected area is observed (reduction of the focus), restoration of neurological status and a decrease in the level of disability in the long-term period.

Pharmacokinetics

Cytoflavin is highly bioavailable.

Succinic acid, when ingested, penetrates from the gastrointestinal tract into the blood and tissues, participating in energy metabolism reactions, and completely decomposes to the final metabolic products (carbon dioxide and water) after 30 minutes.

Inosine is well absorbed from the gastrointestinal tract. The time to reach the maximum concentration in the blood is 5 hours, the average retention time in the blood is 5.5 hours, the equilibrium distribution volume is about 20 liters. Inosine is metabolized in the liver with the formation of inosine monophosphate, followed by its oxidation to uric acid. In a small amount excreted by the kidneys.

Nicotinamide is rapidly distributed in all tissues (equilibrium distribution volume of about 500 liters). The time to reach the maximum concentration in the blood is 2 hours, the average retention time in the blood is 4.5 hours. Nicotinamide passes through the placenta and into breast milk; metabolized in the liver with the formation of N-methylnicotinamide, excreted by the kidneys.

Riboflavin is rapidly absorbed from the gastrointestinal tract, is unevenly distributed (the largest amount in the myocardium, liver, and kidneys), is transformed into flavin adenine mononucleotide (FMN) and flavin adenine dinucleotide (FAD) in the mitochondria. It crosses the placenta and into breast milk; excreted by the kidneys, mainly in the form of metabolites.

In adults in complex therapy:
1. Acute cerebrovascular accident.
2. The consequences of cerebrovascular diseases (consequences of cerebral infarction, cerebral atherosclerosis).
3. Toxic and hypoxic encephalopathy in acute and chronic poisoning, endotoxemia, post-narcotic depression of consciousness, as well as for the prevention and treatment of hypoxic encephalopathy during cardiac surgery using cardiopulmonary bypass.

In children (including premature babies with a gestational age of 28-36 weeks) in complex therapy in the neonatal period:
1. With cerebral ischemia.

Hypersensitivity to patients on mechanical ventilation, with a decrease in the partial pressure of oxygen in arterial blood of less than 60 mm Hg. Art., period of breastfeeding.

With caution - nephrolithiasis, gout, hyperuricemia.

Headache, pain or discomfort in the epigastric region.

Allergic reactions in the form of skin hyperemia and itching are possible. Undesirable reactions include: transient hypoglycemia, hyperuricemia, exacerbation of concomitant gout.

If any of the side effects indicated in the instructions are aggravated or you notice any other side effects not listed in the instructions, inform your doctor.

Succinic acid, inosine and nicotinamide are compatible with other drugs.

Riboflavin reduces the activity of certain antibiotics (tetracyclines, erythromycin, lincomycin), is incompatible with streptomycin.

Ethanol, tricyclic antidepressants, tubular secretion blockers reduce the absorption of riboflavin, and thyroid hormones accelerate its metabolism.

Inside, 2 tablets 2 times a day with an interval between doses of 8-10 hours. Tablets should be taken at least 30 minutes before meals, without chewing, with water (100 ml).

It is recommended to take the drug in the morning and afternoon (no later than 18 hours).

The duration of treatment is 25 days. The appointment of a second course is possible with an interval of at least 1 month.

To date, cases of an overdose of Cytoflavin have not been established.

With hypertension, dose adjustment of antihypertensive drugs may be required.

In patients with diabetes mellitus, treatment is carried out under the control of the concentration of glucose in the blood.

Intensive staining of urine in yellow is possible.

CYTOFLAVIN does not affect: the ability to drive vehicles, work with moving mechanisms, the work of dispatchers and operators.

coated tablets