Decaris (Levamisole)

Tablets.

1 tablet contains:

Active substance:

levamisole hydrochloride - 177 mg, which corresponds to the content of levamizol - 150 mg.

Excipients:

 corn starch,

lactose monohydrate,

sucrose,

talc,

povidon,

magnesium stearate.

Levamisole is an anthelmintic drug.

Acting on ganglion-like formations of nematodes, Dekaris causes depolarizing neuromuscular paralysis of the helminth muscle membrane, blocks succinate dehydrogenase, inhibits fumarate dehydrogenase, disrupting the course of bioenergy processes of helminths.

Thus, paralyzed nematodes are removed from the body by normal intestinal peristalsis within 24 hours after taking the drug.

• Infections with helminths Ascaris lumbrocoides, Necator and Americanus Ancylostoma duodenale.

Prescription of the drug during pregnancy is possible only if the intended benefit to the mother exceeds the potential risk to the fetus.

If it is necessary to use the drug during breastfeeding, the issue of stopping breastfeeding should be resolved.

• Agranulocytosis caused by drugs (in history).
• Children under 3 years of age.
• Breastfeeding period.
• 150 mg tablets are not prescribed to children.

Caution: patients with renal and/or liver failure, depression of bone hematopoiesis.

Headache, insomnia, dizziness, heartbeat, cramps, dyspepsia (nausea, vomiting, abdominal pain, diarrhea).

There are reports of side effects from the CNS (encephalopathy) 2-5 weeks after taking the drug, as well as allergic reactions (skin rash), seizures.

In most patients, these phenomena were reversible, and early use of glucocorticosteroid therapy improved the prognosis.

The connection between these symptoms and Decaris is not quite convincing. When using high doses or long-term therapy, leukopenia, agranulocytosis, tremor may be observed.

When taking the drug with alcohol at the same time, disulfiramic phenomena are observed.

Care is required when using Decaris with drugs that affect hematopoiesis.

When taking the drug with coumarin-like anticoagulants at the same time, the prothrombin time may increase, so it is necessary to adjust the dose of oral anticoagulant. Decaris increases the level of phenytoin in the blood, so when used simultaneously, it is necessary to control the level of phenytoin in the blood.

Decaris cannot be used simultaneously with lipophilic drugs such as tetrachloromethane, tetrachloroethylene, chenopodium oil, chloroform or ether, as its toxicity may increase.

1 tablet 150 mg.

Symptoms: when administered a large dose of levamisole (over 600 mg), the following signs of intoxication were described: nausea, vomiting, drowsiness, seizures, diarrhea, headache, dizziness and confusion.

Treatment: in case of an accidental overdose and if not much time has passed since taking the drug, stomach is washed. It is necessary to monitor vital functions of the body and carry out symptomatic therapy. If there are signs of anticholinesterase action, atropine can be administered.

Alcoholic beverages should not be consumed during and after taking the drug for 24 hours. There is insufficient evidence that levamisole, used as an anthelmintic agent, inhibits the nervous system.

Effect of the drug on the ability to drive a car and other mechanisms

Due to the fact that transient, mild dizziness may occur when taking the drug, care should be taken when driving a car or when working with mechanisms throughout the course of treatment.