Product Overview
Composition
Active substance:
adapalene 1 mg;
Excipients:
carbomer 974P (934 P);
macrogol methyldextrose sesquistearate;
glycerol;
natural squalane;
methyldextrose sesquistearate;
disodium edetate;
methyl parahydroxybenzoate;
propyl parahydroxybenzoate;
phenoxyethanol;
cyclomethicone;
sodium hydroxide;
purified water
pharmachologic effect
Differin is a comedolytic, anti-inflammatory.
Pharmacodynamics
Adapalene is a retinoid metabolite, has comedolytic and anti-inflammatory activity, normalizes the processes of keratinization and epidermal differentiation.
The mechanism of action of adapalene is based on interaction with specific γ-receptors of epidermal skin cells. As a result of the action of adapalene, in particular, there is a decrease in the "cohesion" of epithelial cells at the mouth of the sebaceous hair follicle and a decrease in the prerequisites for the formation of microcomedones.
Adapalene has an anti-inflammatory effect in vivo and in vitro, acting on inflammatory factors by inhibiting the migration of leukocytes in the inflammation focus and the metabolism of arachidonic acid.
Pharmacokinetics
The absorption of adapalene through the skin is very low (about 4% of the applied dose). Excretion from the body occurs mainly through bile.
Indications
Acne.
Application during pregnancy and lactation
Differin is contraindicated in pregnancy and lactation.
Contraindications
Hypersensitivity to one of the ingredients of the drug.
With care: Dermatitis, eczema.
Side effects
Skin irritation (treatment must be suspended until skin irritation disappears or the frequency of use must be reduced).
Interaction
Since the drug does not interact with oxygen and is not destroyed by light, it can be used with other topical and systemic acne medications, such as clindamycin phosphate or benzoyl peroxide.
How to take, course of administration and dosage
Outwardly. With a light touch, evenly apply the gel or cream to the affected surface once a day before going to bed on clean, dry skin, avoiding contact with the eyes and lips.
The therapeutic effect develops after 4–8 weeks of treatment, persistent improvement after 3 months of treatment.
In some cases, due to short-term skin irritation, the number of applications may be reduced or treatment may be suspended until the irritation disappears.
A second course of treatment is possible after consulting a doctor.
Special instructions
Avoid getting the gel or cream in the eyes, lips and mucous membranes.
In case of accidental contact of the drug on the mucous membranes of the eyes, mouth or nose, rinse thoroughly with warm water.
Avoid direct sunlight. slight skin irritation may occur. Treatment can be continued if sun exposure is minimized (use of sunglasses and hats).
The simultaneous use of cosmetics with drying or irritating effect on the skin (for example, perfume or alcohol-containing products) is not recommended.
Adapalene applied to the skin in the evening can be combined with acne medications applied in the morning.
Release form
cream for external use
