Dimexide, 25% 30g

Active substance:

dimexide (dimethyl sulfoxide) 25 g;

Excipients:

methyl parahydroxybenzoate (nipagin) - 0.05 g;

propyl parahydroxybenzoate (nipazole) - 0.013 g;

sodium carmellose (sodium carboxymethyl cellulose) - 2 g;

purified water - up to 100 g

Dimexide is an anti-inflammatory agent with a local analgesic and anti-inflammatory effect. It has a mild antiseptic and fibrinolytic effect.

Dimethyl sulfoxide inhibits inflammatory tissue infiltration. In addition, dimethyl sulfoxide contributes to the normalization of fibrin formation processes, increases microcirculation in tissues, inhibiting the aggregation of erythrocytes, increases the activity of phagocytes, suppresses neutrophil chemotaxis and reduces the content of circulating immune complexes.

Penetrates through the skin, mucous membranes, the cell wall of bacteria (increases their sensitivity to antibiotics) and other biological membranes, increases their permeability to drugs. The drug is low toxic.

Pharmacokinetics

When the drug is applied, dimethyl sulfoxide is detected in the blood serum after 8-15 minutes, and the maximum content is observed after 2-8 hours. As a rule, after 30-36 hours, dimethyl sulfoxide is no longer detected in the blood serum. Dimethyl sulfoxide does not cumulate. With local application of the drug, dimethyl sulfoxide penetrates into the articular cavity, binds to proteins in the blood and tissues.

It is excreted from the body through the kidneys unchanged and in the form of oxidation products - dimethyl sulfone and dimethyl sulfate; as well as in the form of a reduced product (dimethyl sulfide) it is excreted in the exhaled air.

To relieve pain in the complex therapy of the following diseases and conditions:

• rheumatoid arthritis;
• ankylosing spondylitis;
• deforming osteoarthritis;
• arthropathy;
• radiculitis;
• trigeminal neuralgia;
• treatment of bruises;
• damage to the ligaments;
• traumatic infiltrates;
• erythema nodosum therapy.

• hypersensitivity to Dimexide or other components of the drug;
• severe liver and kidney damage;
• angina pectoris;
• myocardial infarction;
• severe atherosclerosis;
• various types of strokes;
• glaucoma, cataracts;
• coma;
• pregnancy;
• lactation period;
• children under 12 years of age.

With caution: due to the fact that Dimexide can enhance not only the activity, but also the toxicity of some drugs, care should be taken when prescribing it simultaneously with other drugs.

In the process of using the drug, contact dermatitis, a garlic smell of exhaled air, increased skin pigmentation, allergic reactions, erythematous rashes, dry skin, and a slight burning sensation can be observed.

Some patients do not perceive well the smell of the drug (nausea, retching), in isolated cases, bronchospasm is possible.

If any of the side effects indicated in the instructions are aggravated or any other side effects not indicated in the instructions appear, you must inform your doctor.

It enhances the penetration of drugs (NSAIDs, antibiotics, etc.) through the skin, which leads to an increase in their activity, in some combinations - to toxicity.

Outwardly.

For adults and children over 12 years of age, the drug is applied in a thin layer to the affected area 1-2 times a day.

Duration of treatment is 10-14 days.

Repeated courses can be held at least 10 days later.

Symptoms: increased dose-related side effects.

Treatment: in these cases, the drug should be canceled, the damaged area should be washed, the drug should be removed.

Taking into account the possibility of individual intolerance to the drug, it is recommended to carry out a drug test for tolerance to it.

For this, the gel is applied in a thin layer to the skin of the elbow bend.

The appearance of sharp redness and itching indicates an increased sensitivity to Dimexide.

If allergic reactions occur during treatment with the drug, the use of the drug is discontinued, blockers of H ₁ -histamine receptors are prescribed .