Product Overview
Composition
100 g of gel contains:
Active substances:
Sodium heparin 50,000 ME
Dexpanthenol 2.500 g
Dimethyl sulfoxide 90% 16.660 g (dry basis) (15.000 g)
Excipients:
Polyacrylic acid 1,000 - 1,400 g,
trometamol 0.200 - 0.300 g,
macrogol glyceryl hydroxystearate (Cremophor SO 455) 1,000 g,
isopropanol 35,000 g,
rosemary oil 0.200 g,
mountain pine oil 0.250 g,
citronella oil 0.050 g,
purified water 42.023 - 42.913 g.
pharmachologic effect
DMSO has anti-inflammatory, decongestant and local analgesic effects.
Anti-inflammatory activity is associated with several pharmacological effects, the most significant of which is the inactivation of hydroxyl radicals, which are produced in large quantities during the inflammation process and have a destructive effect on tissues.
DMSO has a local analgesic effect by reducing the rate of conduction of nociceptive (pain) impulses in peripheral neurons. The anti-edema effect is provided by the inactivation of hydroxyl radicals and the improvement of the subcutaneous metabolic reaction at the site of drug application. To a certain extent, the hygroscopic properties of DMSO are also responsible for its anti-edema effect. DMSO (50% or more) penetrates through biological membranes, including through the skin, contributing to better and deeper penetration into tissues of other drugs used simultaneously with it.
Heparin.
Heparin has an anti-inflammatory effect, promotes the regeneration of connective tissue by inhibiting the activity of hyaluronidase. Heparin exhibits a dose-dependent antithrombotic effect, enhancing the inhibitory activity of antithrombin III on the activation of prothrombin and thrombin. The penetration of heparin through healthy skin is dose dependent and is validated for dosages starting at 300 IU / g.
Dexpanthenol.
Indications
- swelling, bruising and inflammation of soft tissues, muscles, tendons, tendon sheaths,
- closed injuries, bruises,
- joint injuries with sprains of ligaments and tendons,
- epicondylitis of the shoulder ("tennis elbow"), tendinitis (inflammation of the tendons), tendovaginitis (inflammation of the tendon sheaths), bursitis (inflammation of the mucous membrane of the joint bag),
- periarthritis of the shoulder joint,
- acute neuralgia.
Application during pregnancy and lactation
Application during pregnancy.
Since there are no data from studies on the use of the drug in pregnant women, its use during pregnancy is contraindicated.
Application during lactation.
DMSO passes into breast milk, so breastfeeding should be stopped while using the drug.
Recommendations for use
Dolobene should be applied with a surface layer on the skin over the affected skin area 2-4 times a day.
When using a gel under the dressing, apply the gel and wait a few minutes for it to be absorbed by the skin and the isopropanol to evaporate. Then you can apply an airtight bandage.
Dolobene can be used for iontophoresis.
The drug is applied under the cathode. Dolobene as a contact gel can be used in ultrasound therapy (phonophoresis). The active substances of the gel complement the therapeutic effect of ultrasonic waves.
The duration of treatment depends on the severity of the symptoms and the severity of the disease.
Contraindications
- Hypersensitivity to one of the components of the gel (active / excipient),
- bronchial asthma,
- severe dysfunction of the liver, kidneys,
- severe disorders of the cardiovascular system,
- pregnancy and lactation,
- age up to 5 years,
- open wounds at the site of application.
Side effects
Local skin reactions (redness, itching, burning sensation at the site of application of the gel) are possible, which usually disappear during further treatment. Due to the content of DMSO or other components of the drug, an allergic skin reaction is sometimes possible.
In rare cases, during the use of the drug, some patients may experience the smell of garlic from the mouth. The smell is caused by dimethyl sulphide, which is a metabolic product of dimethyl sulfoxide. It is possible to change the taste sensations, which disappear a few minutes after the application of the gel.
Interaction
The application of another drug at the same time as Dolobene can increase their permeability through the skin.
With the simultaneous use of the drug Dolobene and the non-steroidal anti-inflammatory drug Sulindac, the development of peripheral neuropathy is possible.
Overdose
There are no data on drug overdose.
Special instructions
The place of application of the gel should be free of other drugs, cosmetics or any chemicals.
Dolobene should not be applied to the mucous membranes of the eyes, nose, mouth, open wounds or damaged skin areas (due to radiation, severe sunburn), postoperative scars.
During treatment with the drug, the photosensitivity of the skin may increase, therefore, during the period of its use, intense sunbathing and visits to the solarium should be limited.
In case of skin reactions, treatment should be discontinued.
Due to the high absorption of DMSO, Dolobene should not be used in combination with other ointments and gels.
Storage conditions
At a temperature not exceeding 25 ° C. Keep out of the reach of children.
Shelf life
3 years