Elkar 300 mg

1 ml of oral solution contains:

active substance :

levocarnitine (carniphite) 300 mg;

Excipients:

citric acid monohydrate 1.2 mg,  

methyl parahydroxybenzoate 0.5 mg,

propyl parahydroxybenzoate 0.2 mg,

purified water up to 1 ml. 

Elkar is a remedy for the correction of metabolic processes.

L-carnitine (a natural substance related to B vitamins) participates in metabolic processes as a carrier of fatty acids through the cell membranes from the cytoplasm to mitochondria, where these acids are oxidized (beta-oxidation process) with the formation of a large amount of metabolic energy (in the form of ATP ). L-carnitine increases the resistance of the nervous tissue to damaging factors (hypoxia, trauma, intoxication, etc.), inhibits the formation of keto acids and anaerobic glycolysis, and reduces the degree of lactic acidosis.

The drug replenishes the alkaline reserve of blood, helps to restore autoregulation of cerebral hemodynamics and increase blood supply to the affected area, accelerates reparative processes in the lesion focus and has an anabolic effect.

Pharmacokinetics

It is well absorbed in the intestines, the concentration in blood plasma reaches a maximum after 3 hours and remains in the therapeutic range for 9 hours. Easily penetrates the liver, myocardium, more slowly - into the muscles. It is excreted by the kidneys, mainly in the form of acyl esters. 

The drug is used as part of complex therapy.

• intense physical activity and psychoemotional stress: to improve performance, endurance, reduce fatigue, including in the elderly;  
• during the rehabilitation period after diseases and surgical interventions, injuries, including, to accelerate tissue regeneration; 
• complex therapy of chronic gastritis and chronic pancreatitis with reduced secretory function; 
• complex therapy of skin diseases (psoriasis, seborrheic eczema, focal scleroderma and discoid lupus erythematosus); 
• mild hyperthyroidism;
• neurological manifestations in vascular, toxic and traumatic brain lesions; 
• anorexia nervosa syndrome;
• diseases accompanied by a lack of carnitine or its increased loss (myopathy, cardiomyopathy, mitochondrial diseases, hereditary diseases with concomitant mitochondrial insufficiency) - to compensate for its deficiency as part of complex therapy; 
• in pediatric practice (treatment of children under 3 years of age under the supervision of a doctor): when nursing premature babies, newborns who have suffered a birth injury or asphyxiation; children with a sluggish sucking reflex and low body weight gain; reduced muscle tone, with insufficient development of motor and mental functions, as well as for the prevention of these disorders in children of the "risk group"; with growth retardation and underweight in children and adolescents under 16 years of age. 
• in adults in sports medicine and during intensive training (during the period of the training process when working out aerobic performance): to improve speed-strength indicators and coordination of movements, to increase muscle mass and reduce body fat mass, to prevent post-workout syndrome (accelerate recovery processes after physical exertion ), with traumatic injuries in order to accelerate muscle regeneration.

Due to the lack of research, use during pregnancy and lactation is not recommended.

Individual intolerance to the components of the drug.

Allergic reactions, gastralgia, dyspepsia, myasthenia gravis (in patients with uremia) are possible. 

Glucocorticosteroids promote the accumulation of the drug in tissues (except for the liver), other anabolic steroids enhance the effect.

1. The drug is used as part of complex therapy. Inside 30 minutes before meals, additionally diluted with liquid.

With prolonged physical and psycho-emotional stress: from 0.75 g (1/2 measuring spoon or 2.5 ml) 3 times a day to 2.25 g (1.5 measuring spoon or 7.5 ml) 2-3 times day.

With anorexia nervosa, as well as during the rehabilitation period after diseases and surgical interventions and injuries: 1.5 g (1 measuring spoon or 5 ml) 2 times a day. The course of treatment is within 1-2 months.

In the complex therapy of chronic gastritis and chronic pancreatitis with decreased secretory function: 0.375 g (1/4 measuring spoon or 1.25 ml) 2 times a day. The course of treatment is within 1-1.5 months. 

For the treatment of skin diseases: 0.75 g each (1/2 measuring spoon or 2.5 ml). The course of treatment is within 2-4 weeks. 

With mild hyperthyroidism: 0.25 g (13 drops) 2-3 times a day. The course of treatment is 20 days. The course of treatment is repeated after a 1-2 month break or prescribed for 3 months without a break.  

For vascular, toxic and traumatic brain lesions: 0.75 g (1/2 measuring spoon or 2.5 ml) per day. The course of treatment is within 3-5 days. If necessary, a second course is prescribed after 12-14 days. 

For diseases accompanied by a lack of carnitine (primary and secondary carnitine deficiency): up to 50-100 mg / kg (2-5 drops / kg) body weight with a frequency of administration 2-3 times a day. The course of treatment is within 3-4 months. 

Children are prescribed in the form of an additive to sweet dishes (jelly, compote, juices).

For children under 3 years of age, the dose is determined by the attending physician. From 3 to 6 years old - in a single dose of 0.1 g (5 drops) 2-3 times a day, in a daily dose of 0.2-0.3 g (11-16 drops). The course of treatment is 1 month. Children from 6 to 12 years old are prescribed in a single dose of 0.2-0.3 g (11-16 drops) 2-3 times a day, in a daily dose of 0.4-0.9 g (22-48 drops). The course of treatment is at least 1 month. 

With growth retardation: 0.25 g (13 drops) 2-3 times a day. The course of treatment is 20 days. The course of treatment is repeated after a 1-2 month break, or is prescribed for 3 months without a break. 

In sports medicine and with intensive training: 2.5 g 1-3 times a day (daily dose 2.5 -7.5 g); in the case of medical use - 70-100 mg / kg / day (5-7.5 g / day). Reception courses: 3-4 weeks in the pre-competition period. During the training process - up to 6-8 weeks.

2. One ampoule contains 0.5 g of active ingredient.

Elkar is injected intravenously slowly or in a jet (2-3 minutes) or intravenously. Before intravenous administration, the contents of the ampoule are dissolved in 100-200 ml of solvent (0.9% sodium chloride solution or 5% dextrose (glucose) solution).

In acute disorders of cerebral circulation, 1 g / day (2 ampoules) is prescribed for 3 days, and then 0.5 g / day (1 ampoule) for 7 days. After 10-12 days, repeated courses are possible for 3-5 days.

When prescribing the drug in the subacute and recovery period, with discirculatory encephalopathy and various brain lesions, carnitine deficiency, patients are injected with Elcar solution at the rate of 0.5-1 g / day (1-2 ampoules) intravenously (drip, jet) or i / m (2-3 times a day) without dilution for 3-7 days. If necessary, a second course is prescribed after 12-14 days.

Symptoms: dyspeptic disorders, myasthenic disorders (in patients with uremia).

Treatment: gastric lavage, intake of activated carbon.

Treatment of children under the age of 3 years should be carried out under the supervision of a doctor.

The drug does not affect the performance of potentially hazardous activities that require special attention and quick reactions (driving and other vehicles, working with moving mechanisms, the work of a dispatcher and operator, etc.)

Oral solution