Enerion 200 mg 60 pcs.

1 coated tablet contains:

Active substance:

sulbutiamine 200 mg;

Excipients:

corn starch - 12 mg;

dried starch paste - 40 mg;

glucose (dextrose) anhydrous - 20 mg;

lactose monohydrate - 65.5 mg;

magnesium stearate - 3.5 mg;

talc - 9 mg;

Sheath:

sodium bicarbonate - 0.603 mg; sodium carboxymethyl cellulose - 0.556 mg; white beeswax - 0.201 mg; titanium dioxide (E171) - 8.43 mg; ethyl cellulose - 0.485 mg; "Sunset" yellow (Sunset yellow FCF, E110) - 3 mg; glycerol monooleate - 0.242 mg; polysorbate 80 - 0.302 mg; povidone - 0.692 mg; sucrose - 106.956 mg; anhydrous colloidal silicon dioxide (Aerosil 130) - 0.404 mg, talc - 28.21 mg

Enerion drug is a synthetic compound similar in structure to thiamine, in comparison with which the molecule has an open thiazole ring, an additional disulfide bond, and a lipophilic ester.

Thanks to this modification, sulbutiamine is readily soluble in fats, rapidly absorbed from the gastrointestinal tract and easily penetrates the BBB; unlike thiamine, it is able to accumulate in cells of the reticular formation, hippocampus and dentate gyrus, as well as Purkinje cells and glomeruli of the granular layer of the cerebellar cortex.

Against the background of Enerion's reception, coordination of movement improves and resistance to physical exertion increases, the resistance of the structures of the cerebral cortex to repeated anoxia increases. The drug is effective in the symptomatic treatment of functional asthenia.

Pharmacokinetics

Sulbutiamine is rapidly absorbed, C _{max of the} drug in the blood plasma is achieved within 1-2 hours after administration. T _1/2  - about 5 hours. The drug is excreted in the urine.

Symptomatic treatment of functional asthenia.

According to the results of clinical studies, the drug does not affect the development of the fetus.

However, due to the lack of sufficient clinical data, Enerion is not recommended to be taken during pregnancy, as well as during breastfeeding, because it is currently unknown whether sulbutiamine is able to pass into breast milk.

Hypersensitivity to any component of Enerion.

With caution: persons under 18 years of age (the drug is not recommended due to the lack of clinical data).

Allergic reactions (the presence in the composition of the dye "Sunset" yellow), digestive disorders, neuropsychiatric reactions (tremor, headache, agitation, general malaise).

Inside. Enerion is recommended for use only in adult patients.

The daily dose is 2-3 tablets (400-600 mg) in 2 divided doses (during breakfast and lunch).

The duration of treatment should not exceed 4 weeks.

Symptoms: agitation with symptoms of euphoria and tremors of the extremities are transient and do not require special treatment.

The excipients of the Enerion preparation include lactose monohydrate.

As a result, this drug is not recommended for use in persons with lactose deficiency, galactosemia, or glucose / galactose malabsorption syndrome.

Impact on the ability to drive a car and perform work that requires a high speed of psychomotor reactions. Does not affect.

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