Product Overview
Structure
Composition per tablet
Active ingredient:
Nitrofural (furatsilin) ​​- 20 mg
Excipient:
sodium chloride - 800 mg
Active ingredient:
Nitrofural (furatsilin) ​​- 20 mg
Excipient:
sodium chloride - 800 mg
pharmachologic effect
Pharmacodynamics
Antimicrobial derivative of nitrofuran. Bacterial flavoproteins, restoring the 5-nitro group, form highly reactive amino derivatives that can cause conformational changes in proteins (including ribosomal) and other macromolecules, leading to the death of bacteria. Active against gram-positive and gram-negative bacteria (including Staphylococcus spp., Streptococcus spp., Escherichia coli, Clostridium perfringens). Sustainability develops slowly and does not reach a high degree.
Pharmacokinetics
With external and local application, absorption is negligible. Penetrates through histohematological barriers and is evenly distributed in fluids and tissues. The main pathway of metabolism is restoration of the nitro group. It is excreted by the kidneys and partially with bile.
Antimicrobial derivative of nitrofuran. Bacterial flavoproteins, restoring the 5-nitro group, form highly reactive amino derivatives that can cause conformational changes in proteins (including ribosomal) and other macromolecules, leading to the death of bacteria. Active against gram-positive and gram-negative bacteria (including Staphylococcus spp., Streptococcus spp., Escherichia coli, Clostridium perfringens). Sustainability develops slowly and does not reach a high degree.
Pharmacokinetics
With external and local application, absorption is negligible. Penetrates through histohematological barriers and is evenly distributed in fluids and tissues. The main pathway of metabolism is restoration of the nitro group. It is excreted by the kidneys and partially with bile.
Indications
Outwardly: purulent wounds, pressure sores, burns of the II-III degree, minor skin lesions (including abrasions, scratches, cracks, cuts).
Locally: blepharitis, conjunctivitis, osteomyelitis, empyema of the sinuses and pleura; urinary tract infections - flushing cavities, acute tonsillitis, stomatitis, gingivitis.
If necessary, please consult your doctor before using the medicine.
Locally: blepharitis, conjunctivitis, osteomyelitis, empyema of the sinuses and pleura; urinary tract infections - flushing cavities, acute tonsillitis, stomatitis, gingivitis.
If necessary, please consult your doctor before using the medicine.
Pregnancy and lactation
Before using the drug, if you are pregnant, or suspect that you might be pregnant, or are planning a pregnancy, you should consult your doctor during breastfeeding.
Use during pregnancy and during breastfeeding is possible if the intended benefit to the mother outweighs the potential risk to the fetus or baby.
Use during pregnancy and during breastfeeding is possible if the intended benefit to the mother outweighs the potential risk to the fetus or baby.
Contraindications
Hypersensitivity to nitrofural, nitrofuran derivatives and / or other components of the drug, bleeding, allergic dermatoses, severe renal impairment.
Side effects
Allergic reactions, dermatitis, skin itching are possible. If any of the side effects specified in the instructions are aggravated, or any other side effects not listed in the instructions are noted, you should immediately inform your doctor.
Interaction
Not studied.
How to take, course of administration and dosage
Locally, externally, in the form of a 0.02% freshly prepared aqueous solution: immediately before use, one tablet (20 mg of furatsilin) ​​is dissolved in 100 ml of distilled or warm boiled water.
For faster dissolution, hot water is recommended. Then the solution is cooled to room temperature.
Outwardly: in the form of an aqueous 0.02% solution - irrigate the wounds, apply wet dressings.
Locally: blepharitis, conjunctivitis - instillation of an aqueous 0.02% solution into the conjunctival sac. Osteomyelitis after surgery - rinsing the cavity with the subsequent application of a wet dressing.
For faster dissolution, hot water is recommended. Then the solution is cooled to room temperature.
Outwardly: in the form of an aqueous 0.02% solution - irrigate the wounds, apply wet dressings.
Locally: blepharitis, conjunctivitis - instillation of an aqueous 0.02% solution into the conjunctival sac. Osteomyelitis after surgery - rinsing the cavity with the subsequent application of a wet dressing.
Shelf life
5 years.
