Furosemide 40 mg, 56 pills

Renewal, Russia

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$13
Furosemide 40 mg, 56 pills
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Product Overview

Composition

1 tablet contains:

Active substance:

furosemide 40 mg;

Excipients:

lactose;

potato starch;

MCC;

povidone;

gelatin;

magnesium stearate;

colloidal silicon dioxide;

talc.

pharmachologic effect

Furosemide is a natriuretic, diuretic.

Inhibits the reabsorption of sodium ions in the ascending knee of the loop of Henle, proximal and distal tubules.

Increases the excretion of bicarbonates, phosphates, calcium, magnesium.



Indications

  • Edema in case of insufficient blood circulation, liver and kidney diseases, obstruction of venous outflow, after burns and phlebothrombosis; 
  • ascites (against the background of a malignant neoplasm of hepatic and cardiac origin); 
  • peripheral edema; 
  • pulmonary edema, incl. threatening, post-traumatic cerebral edema, arterial hypertension; 
  • pregnancy toxicosis, birth eclampsia, premenstrual tension syndrome, prerenal uremia, hyperkalemia, forced diuresis (poisoning with chemical compounds, including barbiturates).

Contraindications

Hypersensitivity, anuria, uremia, hepatic coma, mechanical obstruction of the urinary tract, dyslectrolythemia.

Side effects

From the side of the cardiovascular system: lowering blood pressure, orthostatic hypotension, collapse, tachycardia, arrhythmias, decreased BCC.

From the side of the central nervous system and peripheral nervous system: dizziness, headache, myasthenia gravis, calf muscle cramps (tetany), paresthesia, apathy, weakness, weakness, lethargy, drowsiness, confusion.

From the senses: impaired vision and hearing.

From the digestive system: decreased appetite, dry mouth, thirst, nausea, vomiting, constipation or diarrhea, cholestatic jaundice, pancreatitis (exacerbation).

From the genitourinary system: oliguria, acute urinary retention (in patients with prostatic hypertrophy), interstitial nephritis, hematuria, decreased potency.

From the hematopoietic system: leukopenia, thrombocytopenia, agranulocytosis, aplastic anemia.

From the side of water and electrolyte metabolism: hypovolemia, dehydration (risk of thrombosis and thromboembolism), hypokalemia, hyponatremia, hypochloremia, hypocalcemia, hypomagnesemia, metabolic alkalosis.

Metabolic disorders: hypovolemia, hypokalemia, hyponatremia, hypochloremia, hypokalemic metabolic alkalosis (as a consequence of these disorders - arterial hypotension, dizziness, dry mouth, thirst, arrhythmia, muscle weakness, convulsions), hyperuricemia (with possible exacerbation of gout), ...

Allergic reactions: purpura, urticaria, exfoliative dermatitis, exudative erythema multiforme, vasculitis, necrotizing angiitis, pruritus, chills, fever, photosensitivity, anaphylactic shock.

Others: with intravenous administration (optional) - thrombophlebitis, renal calcification in premature babies.

Interaction

With the simultaneous use of Furosemide with cardiac glycosides, the risk of developing glycosidic intoxication increases, and when combined with GCS, the risk of hypokalemia.
 
With the simultaneous use of Furosemide potentiates the action of muscle relaxants.
 
With the simultaneous use of Furosemide with aminoglycosides or cephalosporins and cisplatin, their concentration in blood plasma may increase, which can lead to the development of nephro- and ototoxic effects.
 
With the simultaneous use of NSAIDs, the diuretic effect of Furosemide can be reduced.
 
With the simultaneous use of Furosemide and antihypertensive drugs, the hypotensive effect is potentiated.
 
With simultaneous use with Furosemide, the effect of hypoglycemic drugs and pressor amines may be weakened.

How to take, course of administration and dosage

Inside; adults with edema - 40 mg 1 time per day (up to 80-120 mg / day), after increasing urine output, the dose is reduced to a maintenance dose - 40 mg every other day.

For children - at the rate of 1–2 mg / kg / day.

Overdose

Symptoms: decreased blood pressure, collapse, shock, hypovolemia, dehydration, hemoconcentration, arrhythmias, acute renal failure with anuria, thrombosis, thromboembolism, drowsiness, confusion, flaccid paralysis, apathy.

Treatment: correction of water-salt balance and acid-base state (CBS), replenishment of circulating blood volume, symptomatic treatment.

There is no specific antidote.

Special instructions

The drug is prescribed with caution in severe cardiovascular insufficiency, with prolonged therapy with cardiac glycosides, as well as in elderly patients with severe atherosclerosis. Before starting treatment, serious violations of the water and electrolyte balance should be compensated.
 
Control of laboratory parameters
 
During treatment, you should regularly monitor the level of electrolytes, carbonates, urea (especially when using doses above 80 mg).
 
Influence on the ability to drive vehicles and use mechanisms
 
The question of the possibility of engaging in potentially hazardous activities that require increased attention and speed of psychomotor reactions should be resolved after assessing the patient's individual response, due to a possible decrease in the ability to concentrate.

Storage conditions

The drug should be stored in a dry, dark place at a temperature not exceeding 25 ° C.

Shelf life

3 years

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