Product Overview
Structure
1 dose of the drug contains:
active substances: interferon alpha-2b human recombinant * 50,000 IU, taurine 1 mg.
excipients: disodium edetate dihydrate, glycerol, dextran 40000, polysorbate 80, sodium chloride, potassium chloride, sodium hydrogen phosphate dodecahydrate, potassium dihydrogen phosphate, peppermint oil, methyl parahydroxybenzoate, water for injection up to 0.1 ml.
* The substance “Interferon alpha-2b human recombinant (rhIFN-α2b), substance-solution” contains interferon alpha-2b human recombinant (rhIFN-α2b) and excipients: sodium chloride, sodium acetate trihydrate, glacial acetic acid, water for injection.
pharmachologic effect
The antiviral effect is mediated by the activation of a number of intracellular enzymes that inhibit virus replication. The immunomodulatory effect is manifested, first of all, by strengthening the cell-mediated reactions of the immune system, which increases the effectiveness of the immune response against viruses, intracellular parasites and cells that underwent tumor transformation. This is achieved through the activation of CD8 + T-killers, NK-cells (natural killers), increased differentiation.
B-lymphocytes and their production of antibodies, activation of the monocyte-macrophage system and phagocytosis, as well as increased expression of molecules of the main histocompatibility complex of type I, which increases the likelihood of recognition of infected cells by cells of the immune system. Activation of leukocytes contained in all layers of the mucous membrane under the influence of interferon ensures their active
participation in the elimination of pathological foci; in addition, due to the influence of interferon, the production of secretory immunoglobulin A is restored. The antibacterial effect is mediated by reactions of the immune system enhanced by the influence of interferon.
Taurine contributes to the normalization of metabolic processes and tissue regeneration, has a membrane-stabilizing and immunomodulating effect.
Being a strong antioxidant, taurine directly interacts with reactive oxygen species, the excessive accumulation of which contributes to the development of pathological processes. Taurine helps preserve the biological activity of interferon, enhancing the therapeutic effect of the drug.
Pharmacokinetics
With intranasal use due to the high concentration in the focus of infection, a pronounced local antiviral and immunostimulating effect is achieved.
Systemic absorption of the drug is insignificant - the low bioavailability of drugs with intranasal administration is associated with the functioning of a special family of proteins of 25 proteins that are part of the mucous membrane of the nasal cavity and control the transport of all molecular and cellular objects that penetrate the mucosa.
At the same time, a certain amount of the drug enters the systemic circulation, due to which a systemic immunomodulating effect is achieved.Indications
Contraindications
Hypersensitivity to interferon alfa-2b or other components of the drug.
Children under 14 years old.Side effects
Allergic reactions, spotting from the nose are possible.
As a rule, these reactions are mild and do not require additional drug therapy.Interaction
How to take, course of administration and dosage
Individual use is recommended to prevent the spread of infection.
