Product Overview
Structure
Active substance:
ornithine aspartate 5 g;
Excipients:
water for injection - up to 10 ml
pharmachologic effect
Hepa-Merz - hepatoprotective.
Pharmacodynamics
Participates in the ornithine Krebs urea cycle (urea biosynthesis from ammonia). Promotes the production of insulin and STH. Improves detoxification function of the liver, lowers elevated plasma ammonia. Improves protein metabolism in diseases requiring parenteral nutrition.
Pharmacokinetics
Dissociates into ornithine and aspartate, which are absorbed in the small intestine by active transport through the intestinal epithelium. It is excreted in the urine through a urea cycle.
Indications
- acute and chronic liver diseases accompanied by hyperammonemia;
- hepatic encephalopathy (latent and severe), including as part of complex therapy for impaired consciousness (precoma or coma);
- parenteral nutrition of patients with protein deficiency (as a corrective supplement).
Contraindications
Severe renal impairment (plasma creatinine level 3 mg / 100 ml).
Side effects
Rarely - skin reactions, in some cases - nausea, vomiting.
How to take, course of administration and dosage
Intravenously, usually 20 g (4 ampoules), with hepatic encephalopathy, depending on the severity of the condition, up to 40 g (8 ampoules) per day; the maximum infusion rate is 5 g / h.
Release form
Concentrate for solution for infusion
