Product Overview
Composition
100 g of gel contain: active substance: sodium heparin in terms of dry matter - 0.83 g (100,000 ME); excipients: methyl parahydroxybenzoate - 0.15 g, carbomer 940 - 1.25 g, trometamol - 0.85 g, ethanol 96% (rectified ethyl alcohol) - 24 g, lavender oil - 0.02 g, orange blossom oil (neroli oil) - 0.01 g, purified water - up to 100 g.
Pharmacological properties
Pharmacodynamics Direct anticoagulant, has anti-inflammatory, antiproliferative, decongestant and analgesic effects. Reduces platelet aggregation, binds to antithrombin III, preventing the transition of prothrombin to thrombin. Inhibits the activity of thrombin. Reduces the activity of hyaluronidase, increases the fibrinolytic properties of blood. Improves microcirculation and activates tissue metabolism, thereby accelerating the processes of resorption of hematomas and blood clots, ultimately restoring the patency of veins, clinically accompanied by a pronounced analgesic and anti-inflammatory effect.
Pharmacokinetics
A small amount of heparin is absorbed from the skin surface into the systemic circulation. The maximum concentration of the active substance in the blood is observed 8 hours after application. Excretion of heparin mainly occurs through the kidneys, with a half-life of 12 hours.
A small amount of heparin is absorbed from the skin surface into the systemic circulation. The maximum concentration of the active substance in the blood is observed 8 hours after application. Excretion of heparin mainly occurs through the kidneys, with a half-life of 12 hours.
Indications
- Thrombophlebitis of superficial veins;
- localized infiltrates and swelling of soft tissues;
- Injuries to tendons and joints;
- bruises of soft tissues and joints.
- localized infiltrates and swelling of soft tissues;
- Injuries to tendons and joints;
- bruises of soft tissues and joints.
Contraindications
- Hypersensitivity to any of the components of the drug,
- ulcerative necrotic changes in the skin at the sites of the intended application of the gel,
- traumatic violation of the integrity of the skin,
- decreased blood clotting,
- thrombocytopenia.
- ulcerative necrotic changes in the skin at the sites of the intended application of the gel,
- traumatic violation of the integrity of the skin,
- decreased blood clotting,
- thrombocytopenia.
Side effects
- Skin allergic reactions,
- skin hyperemia.
- skin hyperemia.
Interaction
It is not recommended to mix with other external products. Do not prescribe topically simultaneously with non-steroidal anti-inflammatory drugs, tetracyclines, antihistamines.
The combined use of the gel with oral anticoagulants can cause prolongation of prothrombin time.
The combined use of the gel with oral anticoagulants can cause prolongation of prothrombin time.
How to take, course of administration and dosage
Outwardly.
The gel is applied in a thin layer to the affected area at the rate of 3-5 cm of gel on a skin with a diameter of 3-5 cm and gently rubbed into the skin. Apply 1-3 times a day every day until the inflammation disappears, on average from 3 to 7 days. The terms of treatment are determined by the doctor.
The gel is applied in a thin layer to the affected area at the rate of 3-5 cm of gel on a skin with a diameter of 3-5 cm and gently rubbed into the skin. Apply 1-3 times a day every day until the inflammation disappears, on average from 3 to 7 days. The terms of treatment are determined by the doctor.
Overdose
Overdose is unlikely due to the low absorption of the components of the gel. It is manifested by bleeding. It is removed with protamine sulfate (chemical antagonist).
Special instructions
It is not recommended for use in case of bleeding, as well as on open wounds, mucous membranes and in the presence of local purulent processes.
Use with extreme caution in case of increased vascular permeability.
The use of the gel is not recommended for deep venous thrombosis.
Use with extreme caution in case of increased vascular permeability.
The use of the gel is not recommended for deep venous thrombosis.
Release form
Gel for external use.
Storage conditions
At temperatures from 15 to 25 ° C.
Keep out of the reach of children.
Keep out of the reach of children.
Shelf life
2 years.
