Ingaron (Interferon Gamma) lyophilisate 500 000 ME , 5 pcs.

Active substance:

interferon gamma 500 thousand ME;

Excipient:

 mannitol

Ingaron® - recombinant human gamma interferon, consists of 144 amino acid residues (amino acid residues), is devoid of the first three amino acid residues - Cys-Tyr-Cys replaced by Met. The molecular weight is 16.9 kDa. Obtained by microbiological synthesis in a recombinant strain of Escherichia coli and purified by column chromatography.

The specific antiviral activity on the cells (human fibroblasts) infected with the virus of vesicular stomatitis is 2 · 107 U / mg protein. Interferon gamma (immune interferon) is the most important pro-inflammatory cytokine whose producers in the human body are natural killer cells, CD4 Th1 cells and CD8 cytotoxic suppressor cells.

Interferon gamma receptors have macrophages, neutrophils, natural killer cells, cytotoxic T-lymphocytes. Interferon gamma activates the effector functions of these cells, in particular their microbicidal activity, cytotoxicity, production of cytokines, superoxide and nitrooxide radicals, thereby causing the death of intracellular parasites.

Interferon gamma inhibits the B-cell response, IL-4, inhibits the production of IgE and expression of the CD23 antigen. It is an inducer of apoptosis of differentiated B cells, giving rise to autoreactive clones. It cancels the suppressive effect of IL-4 on IL-2-dependent proliferation and the generation of lymphokinactivated killers. It activates the production of proteins of the acute phase of inflammation, enhances the expression of genes C2 and C4 of the components of the complement system.

Unlike other interferons, it increases the expression of antigens of the main histocompatibility complex (HCH) of both the 1st and 2nd classes on different cells, and induces the expression of these molecules even on those cells that do not express them constitutively. This increases the efficiency of the presentation of antigens and the ability of their recognition by T-lymphocytes.

Interferon gamma blocks the replication of viral DNA and RNA, the synthesis of viral proteins and the assembly of mature viral particles. Interferon gamma has a cytotoxic effect on virus-infected cells.

Interferon gamma blocks the synthesis of β-TGF, responsible for the development of pulmonary fibrosis and liver.

Complex therapy:

• chronic viral hepatitis C;
• chronic viral hepatitis B;
• HIV / AIDS infection;
• pulmonary tuberculosis;
• oncological diseases (as an immunomodulator - including in combination with chemotherapy);
• urogenital chlamydia;
• chronic prostatitis;
• genital herpesvirus infection and herpes zoster (Herpes zoster) - in monotherapy;
• anogenital warts (human papillomavirus) - treatment and prevention of relapse of the disease.

Prevention of infectious complications in patients with chronic granulomatous disease.

Ingaron is contraindicated in pregnancy

• individual intolerance to interferon gamma or any other component of the drug;
• pregnancy;
• autoimmune diseases;
• diabetes.

Local soreness at the site of sc administration in the form of a weak pain of a breaking nature (like an overtrained muscle) and hyperemia.

The use of doses in excess of 1 million ME can be accompanied by the development of a flu-like syndrome: headache, weakness, fever, joint pain. Mild symptoms do not require pharmacological correction. With severe phenomena - stopping with paracetamol.

Intramuscularly, subcutaneously. The contents of the vial are dissolved in 2 ml of water for injection. The dose of the drug is set individually.

For the treatment of patients with chronic viral hepatitis B, chronic viral hepatitis C, as well as HIV / AIDS and pulmonary tuberculosis, the average daily dose for adults is 500 thousand ME. It is administered 1 time per day, daily or every other day. The course of treatment is from 1 to 3 months, if necessary, after 1-2 months, the treatment is repeated.

For the prevention of infectious complications in patients with chronic granulomatous disease, usually the average daily dose for adults is 500 thousand ME. It is administered 1 time per day, daily or every other day. The course - 5-15 injections, if necessary, the course is extended or repeated after 10-14 days.

For the treatment of cancer, the average daily dose for adults is 500 thousand ME. It is administered 1 time per day, every other day.

For the treatment of genital herpes virus infection, herpes zoster (Herpes zoster) and urogenital chlamydia, the average daily dose for adults is 500 thousand IU. It is introduced 1 time per day, s / c, every other day. The course of treatment is 5 injections.

For the treatment of chronic prostatitis, the daily dose is 100 thousand IU. It is introduced once a day s / c, every other day. The course of treatment is 10 injections.

For the treatment of anogenital warts, the daily dose is 100 thousand IU. It is administered once a day s / c, after cryodestruction, every other day. The course of treatment is 5 injections.

Lyophilisate for solution for intramuscular and subcutaneous administration