Product Overview
Structure
Active substance :
interferon gamma 100 thousand ME (5.5 ± 0.5);
Excipients:
mannitol
pharmachologic effect
Ingaron® - recombinant human gamma interferon, consists of 144 amino acid residues (amino acid residues), is devoid of the first three amino acid residues - Cys-Tyr-Cys replaced by Met. The molecular weight is 16.9 kDa. Obtained by microbiological synthesis in a recombinant strain of Escherichia coli and purified by column chromatography. The specific antiviral activity on the cells (human fibroblasts) infected with the virus of vesicular stomatitis is 2 · 107 U / mg protein.
Interferon gamma (immune interferon) is the most important pro-inflammatory cytokine whose producers in the human body are natural killer cells, CD4 Th1 cells and CD8 cytotoxic suppressor cells. Interferon gamma receptors have macrophages, neutrophils, natural killer cells, cytotoxic T-lymphocytes.
Interferon gamma activates the effector functions of these cells, in particular their microbicidal activity, cytotoxicity, production of cytokines, superoxide and nitrooxide radicals, thereby causing the death of intracellular parasites. Interferon gamma inhibits the B-cell response, IL-4, inhibits the production of IgE and expression of the CD23 antigen. It is an inducer of apoptosis of differentiated B cells, giving rise to autoreactive clones. It cancels the suppressive effect of IL-4 on IL-2-dependent proliferation and the generation of lymphokinactivated killers. It activates the production of proteins of the acute phase of inflammation, enhances the expression of genes C2 and C4 of the components of the complement system.
Unlike other interferons, it increases the expression of antigens of the main histocompatibility complex (HCH) of both the 1st and 2nd classes on different cells, and induces the expression of these molecules even on those cells that do not express them constitutively. This increases the efficiency of the presentation of antigens and the ability of their recognition by T-lymphocytes.
Interferon gamma blocks the replication of viral DNA and RNA, the synthesis of viral proteins and the assembly of mature viral particles. Interferon gamma has a cytotoxic effect on virus-infected cells.
Interferon gamma blocks the synthesis of β-TGF, responsible for the development of pulmonary fibrosis and liver.
Indications
Combined therapy for the prevention and treatment of influenza and avian influenza (H5N1 and H1N1).
Pregnancy and lactation
Ingaron is contraindicated in pregnancy
Contraindications
- individual intolerance to interferon gamma or any other component of the drug;
- pregnancy;
- children under 7 years old.
How to take, course of administration and dosage
Intranasally. The contents of the vial are dissolved in 5 ml of water for injection.
At the first sign of flu, SARS - 2 drops in each nasal passage, after the toilet of the nasal passages, 5 times a day for 5-7 days.
For the prevention of acute respiratory viral infections and influenza in contact with the patient and / or during hypothermia - 2-3 drops in each nasal passage every other day 30 minutes before breakfast for 10 days. If necessary, preventive courses are repeated. With a single contact, one instillation is enough.
After instillation, it is recommended to massage the wings of the nose with your fingers for several minutes to evenly distribute the drug in the nasal cavity.
Release form
Lyophilisate for solution for intranasal administration
