Lidase lyophilizate (Hyaluronidase) 1280IU 10 vials

Microgen NPO, Russia

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Product Overview

Pharmacological action

Enzyme preparation isolated from cattle testicles.
 
It decomposes the main component of the interdone substance of connective tissue - hyaluronic acid (mucopolysaccharide, which includes acetylglucosamine and glucuronic acid.

Indications

Burn, traumatic, postoperative scars; long-term non-healing ulcers
(including radial contracture); Dupuytren's contracture; joint stiffness, joint contractures (after inflammatory processes, injuries), osteoarthritis, ankylosing spondylitis, severe diseases of lumbar discs; chronic tendovaginitis, scleroderma (skin manifestations), soft tissue hematoma of surface localization; preparation for skin and plastic operations for scar tightening.
 
Pulmonary tuberculosis (complicated by non-specific bronchial lesions), inflammatory processes in the upper respiratory tract and bronchi with obstruction. Traumatic lesions of nerve plexus and peripheral nerves (plexitis, neuritis). Hyphema, hemophthalmos, retinopathy of various etiologies.

Recommendations for use

In case of scar lesions subcutaneously (under scar-altered tissues) or intramuscularly (near the site of the lesion), 64 UE (1 ml) is administered daily or every other day (only 10-20 injections).

In case of traumatic lesions of the nerve plexus and peripheral nerves, it is injected subcutaneously into the area of the affected nerve (64 UE in procaine solution) every other day; for the course - 12-15 injections. The course of treatment is repeated if necessary.

When used in ophthalmic practice, the drug is administered subconjunctivally - 0.3 ml, parabulbar - 0.5 ml, as well as by electrophoresis.

Patients with pulmonary tuberculosis with a productive nature of inflammation are prescribed in complex therapy to increase the concentration of antibacterial drugs in the lesions in the form of injections and/or inhalations. Inhalations are carried out daily 1 time, using 5 ml of solution (320 UE). The course of treatment consists of 20-25 inhalations. If necessary, repeated courses are held at intervals of 1.5-2 months.

In the form of bandages impregnated with a solution of the drug. To prepare the solution, every 64 UE is dissolved in 10 ml of sterile 0.9% solution of sodium chloride or boiled water at room temperature. This solution is moistened with a sterile bandage folded in 4-5 layers, applied to the affected area, covered with waxed paper and fixed with a soft bandage. The dose depends on the area of the lesion
(32-64 UE/sq.cm), on average - 320 UE per bandage. The bandage is applied daily on
15-18 hours for 15-60 days. With long-term use every 2 weeks, take a break for 3-4 days.

When applied by electrophoresis, 320 UE is dissolved in 64 ml of distilled water, 2-3 drops of 0.1% hydrochloric acid solution are added and injected from the anode to the affected area for 20-30 minutes. The course of treatment is 15-20 sessions. The application dosing regimen can be alternated with electrophoresis. The prepared solution should be used within 24 hours.

Contraindications

Hypersensitivity, acute infectious and inflammatory diseases, recent hemorrhages.

For inhalation - pulmonary tuberculosis with severe respiratory failure; pulmonary bleeding, hemoptysis; malignant neoplasms, fresh vitreous hemorrhage. Concomitant intake of estrogens.

With caution: pregnancy, lactation period

Side effects

Allergic reactions; with long-term use - locally irritating effect.

Interaction

Improves the absorption of drugs administered subcutaneously or intramuscularly, enhances the effect of local anesthetics.

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