Magne B6 10 ml , 10 pcs.

Active ingredients:

magnesium lactate dihydrate - 186 mg;

magnesium pidolate - 936 mg;

 pyridoxine hydrochloride - 10 mg; 

Excipients:

 sodium disulfite - 15 mg,

sodium saccharinate - 15 mg,

cherry-caramel flavoring - 0.3 ml,

purified water up to 10 ml;

Magnesium is a vital element that is found in all tissues of the body and is necessary for the normal functioning of cells, participates in most metabolic reactions. In particular, it is involved in the regulation of nerve impulse transmission and muscle contraction. The body gets magnesium from food.

Lack of magnesium in the body can be observed in violation of the diet (diet) or with an increase in the need for magnesium (with increased physical and mental stress, stress, pregnancy, use of diuretics). Pyridoxine (vitamin B ₆ ) is involved in many metabolic processes, in the regulation of the metabolism of the nervous system. Vitamin B ₆  improves the absorption of magnesium from the gastrointestinal tract and its penetration into cells. 

Serum magnesium content:

• from 12 to 17 mg / l (0.5 - 0.7 mmol / l) indicates a moderate magnesium deficiency;
• below 12 mg / L (0.5 mmol / L) indicates severe magnesium deficiency.

Pharmacokinetics 

Absorption of magnesium in the gastrointestinal tract is no more than 50% of the oral dose. 99% of the magnesium in the body is found inside cells.

Approximately 2/3 of intracellular magnesium is distributed in bone tissue, and the other 1/3 is in smooth and striated muscle tissue. Magnesium is excreted mainly in the urine. At least 1/3 of the dose of magnesium is excreted in the urine.

• Established magnesium deficiency, isolated or associated with other deficiency conditions, accompanied by symptoms such as: increased irritability, minor sleep disturbances; 
• gastrointestinal cramps or heart palpitations; 
• increased fatigue, pain and muscle spasms, tingling sensation.

Pregnancy 

Clinical experience of using the drug in a sufficient number of pregnant women did not reveal any adverse effect on the occurrence of fetal malformations or fetotoxic effects. 
Magne B ₆ ^®  can be used during pregnancy only if necessary, on the advice of a doctor. 

Breastfeeding period 

Magnesium passes into breast milk. Avoid using the drug during lactation and breastfeeding.

• Hypersensitivity to drug components.
• Severe renal failure (creatinine clearance less than 30 ml / minute).
• Phenylketonuria.
• Children under 6 years of age (for the drug in the form of tablets) and up to 1 year (for solution).
• Fructose intolerance, glucose-galactose malabsorption syndrome, sucrase-isomaltase deficiency (only for the drug in the form of tablets due to the presence of sucrose in the composition).
• Simultaneous administration of levodopa.

With caution: with a moderate degree of renal failure, as there is a risk of developing hypermagnesemia.

Allergic reactions, including skin reactions. 

Adults are advised to take 3-4 ampoules per day.

For children over 1 year old (body weight over 10 kg), the daily dose is 10-30 mg magnesium / kg body weight (0.4-1.2 mmol magnesium / kg) or 1-4 ampoules.

The daily dose should be divided into 2-3 doses, taken with meals.

The tablets should be taken with a glass of water.

The solution from the ampoules is dissolved in a glass of water before taking.

Treatment should be discontinued immediately after the normalization of the concentration of magnesium in the blood.

Symptoms: With normal kidney function, an overdose of magnesium when taken orally usually does not lead to toxic reactions. However, in the case of renal failure, magnesium poisoning may develop.

Overdose symptoms, the severity of which depends on the concentration of magnesium in the blood: lowering blood pressure; nausea, vomiting; oppression of the central nervous system, decreased reflexes; changes in the electrocardiogram; respiratory depression, coma, cardiac arrest and respiratory paralysis; anuric syndrome. 

Treatment: rehydration, forced diuresis. Renal failure requires hemodialysis or peritoneal dialysis.