Product Overview
Composition
naftifine hydrochloride - 10.0 mg.
Excipients:
propylene glycol - 50.0 mg,
ethanol (ethyl alcohol 95%) - 400.0 mg,
purified water - up to 1 ml.
pharmachologic effect
Mikoderil ® is an antifungal drug for external use, the active ingredient of which is naftifine. Naftifine is an antifungal agent belonging to the allylamine class. The mechanism of action is associated with inhibition of squalene-2,3-epoxidase, which leads to a decrease in the formation of ergosterol, which is part of the cell wall of the fungus. Naftifine, affecting squalene epoxidase, does not affect the cytochrome P-450 system.
Naftifine is active against dermatophytes such as Trichophyton, Epidermophyton, Microsporum, yeast and yeast-like fungi (Candidaspp., Pityrosporum), molds (Aspergillus) and other fungi (for example Sporothrixschenckii). In relation to dermatophytes and aspergillus, naftifine has a fungicidal effect.
In relation to yeast fungi, the preparation exhibits fungicidal or fungistatic activity, depending on the strain of the microorganism. Naftifine has antibacterial activity against gram-positive and gram-negative microorganisms that cause secondary bacterial infections.
Naftifine has an anti-inflammatory effect, which promotes the rapid disappearance of symptoms of inflammation, especially itching.
Pharmacokinetics
When applied externally, naftifine quickly penetrates the skin, creating stable antifungal concentrations in its various layers, which makes it possible to use it once a day.Indications
- Fungal infections of smooth skin and skin folds (tinea corporis, tinea inquinalis);
- interdigital mycoses (tinea manum, tinea pedum);
- fungal infections of the nails (onychomycosis);
- candidiasis of the skin;
- pityriasis versicolor;
- inflammatory dermatomycosis (with or without itching).
Application during pregnancy and lactation
Contraindications
Hypersensitivity to naftifine or propylene glycol; pregnancy and the period of breastfeeding (the safety and efficacy of the drug in this category of patients has not been studied).
Application of the drug to the wound surface is contraindicated.
Children's age (clinical experience is limited).
Side effects
Interaction
How to take, course of administration and dosage
With dermatomycosis and candidiasis of the skin.
Micoderil®, spray for external use, 1% is applied once a day to the affected skin surface and adjacent areas after thorough cleaning and drying, capturing approximately 1 cm of healthy skin along the edges of the affected area. Duration of treatment: with dermatomycosis - 2-4 weeks (if necessary - up to 8 weeks), with candidiasis - 4 weeks.
With nail lesions (onychomycosis).
Before the first use of the drug, the affected part of the nail is removed as much as possible with scissors and a nail file. The drug is used 2 times a day, the duration of treatment for onychomycosis is up to 6 months. To prevent recurrence of infection, the drug should be continued for at least 2 weeks after the disappearance of clinical symptoms.
If after treatment there is no improvement or the symptoms worsen, or new symptoms appear, you should consult your doctor. Use the drug only according to the indications, the method of administration and the doses indicated in the instructions for use.
Overdose
Special instructions
Read the instructions for use carefully before using this medicine, as it contains important information for you.
- Keep the instructions, you may need them again.
- If you have any questions, see your doctor.
- The drug you are treating is intended for you personally and should not be used by others, as it can harm them even if they have the same symptoms as you.
Mikoderil®, spray for external use, 1% is effective in the treatment of mycoses affecting areas of the skin with hyperkeratosis, as well as in areas of hair growth.
Course treatment is required.
Avoid contact with eyes and open wounds.
Use in pediatrics
The drug should be used with caution in children.
Mikoderil®, spray for external use, 1% does not adversely affect the ability to drive vehicles and perform other activities that require concentration and psychomotor speed.
Storage conditions
Keep out of the reach of children.
