Minolexin (Minocycline)

Active substances:

minocycline hydrochloride dihydrate (in terms of minocycline) 100 mg;  

Excipients:

 microcrystalline cellulose,

low molecular weight povidone,

potato starch,

magnesium stearate,

lactose monohydrate.

Minolexin is a semi-synthetic antibiotic from the tetracycline group. It has a bacteriostatic effect on cells of sensitive strains of microorganisms due to reversible inhibition of protein synthesis at the level of 30S subunits of ribosomes. It has a wide range of antibacterial activity.

The sensitivity of microorganisms:

Some of the following microorganisms have shown resistance to minocycline, therefore, laboratory tests are recommended before use. sensitivity study. Antibiotics of the tetracycline group are not recommended for the treatment of streptococcal and staphylococcal infections, unless the sensitivity of microorganisms to minocycline is shown.

Gram-positive aerobic: Bacillus anthracis, Listeria monocytogenes, Staphylococcus aureus, Streptococcus pneumoniae.

Gram-negative aerobic: Bartonella bacilliformis, Brucella species, Calymmatobacterium granulomatis, Campylobacterfetils, Francisella tularensis, Haemophilus ducreyi, Vibrio cholerae, Yersinia pestis.

Minolexin is used to treat the following diseases, provided the sensitivity of pathogenic microorganisms:

• Acne
• Skin infections
• Spotted fever, typhoid fever, typhoid fever, Q fever (coxiellosis), vesicular rickettsiosis and tick-borne fever
• Respiratory tract infections
• Lymphogranuloma venereal
• Ornithosis
• Trachoma (infectious keratoconjunctivitis)
• Conjunctivitis with inclusions (paratrachoma)
• Non-neococcal urethritis, infections of the cervical canal and anus in adults
• Cyclic fever
• Chancroid
• Plague
• Tularemia
• Cholera
• Brucellosis
• Bartonellosis
• Inguinal granuloma
• Syphilis
• Gonorrhea
• Frambesia (tropical granuloma, non-venereal syphilis)
• Listeriosis
• anthrax
• Angina Vincent
• Actinomycosis.

In the case of acute intestinal amoebiasis, the use of minocycline as a supplement to amoebicidal drugs is allowed.

In severe acne. minocycline can be used as adjunctive therapy.

Oral administration of minocycline is indicated for asymptomatic carriage of Neisseria mepigitidis to eradicate meningococci from the nasopharynx.

• Hypersensitivity to minocycline, tetracyclines and other components of the drug
• Porphyria
• Severe hepatic and renal failure
• Leukopenia
• Pregnancy
• Breast-feeding
• Systemic lupus erythematosus
• Children's age up to 8 years (period of tooth development)
• Concomitant use with isotretinoin
• Lactase deficiency, lactose intolerance, glucose-galactose malabsorption.  

With caution: impaired liver and kidney function, simultaneous use with hepatotoxic drugs.

On the part of the digestive system: anorexia, nausea, vomiting, diarrhea, dyspepsia, stomatitis, glossitis, dysphagia, hypoplasia of tooth enamel, enterocolitis, pseudomembranous colitis, pancreatitis, inflammatory
lesions (including fungal) in the oral cavity and anogenitalia, hypogenesis, anogenitalia, anogenitalia, anogenital, , cholestasis, an increase in the content of “liver” enzymes, liver failure, including terminal, hepatitis, including autoimmune.

From the genitourinary system: candidal vulvovaginitis, interstitial nephritis, dose-dependent increase in urea in the blood plasma.

From the skin: baldness, erythema nodosum, nail pigmentation, itching, toxic epidermal necrosis, vasculitis, maculopapular and erythematous rash, Stevens-Johnson syndrome, exfoliative dermatitis, balanitis.

From the respiratory tract: shortness of breath, bronchospasm, exacerbation of asthma, pneumonia.

From the musculoskeletal system: arthralgia, arthritis, limited mobility and swelling of the joints, discoloration of bone tissue, muscle pain (myalgia).

Allergic reactions: urticaria, angioedema, polyarthralgia, anaphylactic reactions (including shock), anaphylactoid purpura (Purple Schoenlein Genoch), pericarditis, exacerbations of systemic lupus erythematosus, pulmonary infiltration, accompanied by eosinophilia.

From the hemopoietic organs: agranulocytosis, hemolytic anemia, tr6mbocytopenia, leukopenia, neutrocytopenia, pancytopenia, eosinopenia, eosiophilia.

From the central nervous system: cramps, dizziness, numbness (including limbs), lethargy, vertigo, increased intracranial pressure in adults, headaches.

From the sensory organs: tinnitus and hearing impairment.

From the side of metabolism: Thyroid gland: an isolated case of a malignant neoplasm, discoloration (according to the results of patho-morphological studies), impaired function.

Other: Change in color of the oral cavity (tongue, gum, palate), change in color of tooth enamel, fever, discharge color (for example, sweat).

The drugs of the tetracycline group reduce the prothrombin activity of blood plasma, which may necessitate a reduction in the doses of anticoagulants in patients undergoing anticoagulant therapy.

Due to the fact that bacteriostatic drugs affect the bactericidal effect of penicillins, the simultaneous administration of penicillin and tetracycline groups should be avoided.

The absorption of tetracyclines is impaired when taken with antacids containing aluminum, calcium, magnesium or iron-containing drugs, which can lead to a decrease in the effectiveness of antibiotic therapy.

There have been cases of terminal renal toxicity while taking methoxyfruran and drugs of the
tetracycline group.

The simultaneous use of antibiotics of the tetracycline group and oral contraceptives can lead to a decrease in the effectiveness of contraception.

You should avoid taking isotretinoin immediately before, simultaneously and immediately after taking minocycline, since both drugs can cause a benign increase in intracranial pressure.

The simultaneous use of drugs of the tetracycline group with ergot alkaloids and their derivatives increases the risk of ergotism.

Inside, after a meal. It is recommended to drink plenty of fluids (can be milk) for. reduce the risk of irritation and ulceration in the esophagus.

The initial dose of Minolexin is 200 mg (2 capsules of 100 mg or 4 capsules of 50 mg), then take 100 mg (1 capsule of 100 mg or 2 capsules of 50 mg) every 12 hours (twice a day).

The maximum daily dose should not exceed 400 mg.

Infections of the genitourinary system and anogenital region caused by chlamydia and ureaplasma: 100 mg (1 capsule of 100 mg or 2 capsules of 50 mg) every 12 hours for 7-10 days.

Inflammatory diseases of the pelvic organs in women in the acute stage: 100 mg (1 capsule of 100 mg or 2 capsules of 50 mg) every 12 hours, sometimes in combination with cephalosporins.

Primary syphilis in patients. with hypersensitivity to penicillins: 100 mg (1 capsule of 100 mg or 2 capsules of 50 mg) twice a day for 10 to 15 days.

Gonorrhea: 100 mg (1 capsule of 100 mg or 2 capsules of 50 mg) twice a day for 4-5 days, or once 300 mg.

Uncomplicated gonococcal infections (excluding urethritis and anorectal infections) in men: initial dose - 200 mg (2 capsules of 100 mg or 4 capsules of 50 mg), supporting - 100 mg (1 capsule of 100 mg or 2 capsules of 50 mg) through every 12 hours for a minimum of 4 days, followed by a microbiological assessment of recovery 2-3 days after stopping the drug.

Uncomplicated gonococcal urethritis in men: 100 mg (1 capsule of 100 mg or 2 capsules of 50 mg) every 12 hours for 5 days.

Acne: 50 mg (1 capsule of 50 mg) per day, with a long course of 6-12 weeks.

Symptoms: Dizziness, nausea, and vomiting are most commonly observed.

Treatment: The selective antidote for minocycline is currently unknown. In case of an overdose, it is necessary to stop taking the drug, provide symptomatic treatment and supportive therapy. Hemo- and peritoneal dialysis remove minocycline in small quantities.

Hard gelatin capsules, No. 2, with a body and a white lid; the contents of the capsules are yellow powder.