Nemozole

Each film-coated tablet contains:

Pharmacotherapy group:

anthelmintic and antiprotozoal agent.

ATX code: P02CA03

Pharmacological properties

Pharmacodynamics

Albendazole is an anthelmintic drug, the pharmacological properties of which are due to the action of the active substance - albendazole. Albendazole belongs to the group of carbamatbenzimidazoles. The mechanism of action of albendazole is its ability to disrupt the activity of the microtubular system of helminth intestinal cells, causing damage to the tubulin protein. The consequence of this is biochemical disorders in the cell - inhibition of glucose and fumaratreductose transport, which is the basis for cell division suppression at the metaphase stage and which is associated with egg laying suppression and the development of helminth larvae. Albendazole blocks the movement of secretory granules and other organelles in the muscle cells of roundworms, causing their death.

Albendazole is effective for most intestinal nematodes, as well as larval (larval stages) cestodes, as well as lambliums. Albendazole as an antiparasitic drug has a fairly wide range of effects.

Pharmacokinetics

Suction. After ingestion, the drug is poorly absorbed in the gastrointestinal tract, and is not determined unchanged in blood plasma. Bioavailability when taken orally is low. Taking fatty food increases absorption and maximum concentration by 5 times.

Metabolism. Albendazole quickly turns into the primary metabolite -albendazole sulfoxide in the liver, which also has anthelmintic activity.

Distribution. The maximum plasma concentration of albendazole sulfoxide is reached 2-5 hours after administration. 70% of the metabolite is associated with plasma proteins and completely spreads throughout the body: it is found in urine, bile, liver, wall and fluid of helminth cysts, cerebrospinal fluid.

Withdignment. Albendazole sulfoxide in the liver turns into albendazole sulfon (secondary metabolite) and other oxidized products. The half-life of sulfoxide albendazole is 8-12 hours. It is excreted through the kidneys in the form of various metabolites. The excretion of albendazole and albendazole sulfoxide through the kidneys is insignificant. In patients with kidney dysfunction, clearance does not change.

In patients with liver damage, bioavailability increases, the maximum concentration of sulfoxide albendazole in blood plasma increases by 2 times, and the half-life is extended.

Albendazole induces cytochrome SUR1A2 in human liver cells, accelerates the metabolism of many drugs.

- Nematodes:
ascaris, pathogen - round helminth Ascaris lumbricoidesl;
trichocephalus (vlasoglav), causative agent - round helminth Trichocephalus trichiurus;
enterobiasis (pits), causative agent - round helminth Enterobius vermicularis;
ankylostomidose (curved head), pathogens - Ancylostoma duodenale and Necator americanus;
trichinellosis, pathogen - Trichinella spiralis;
toxocarasis, pathogen - Toxocara canis;
lambliosis, pathogen - Giardia intestinalis;
- tissue cestodoses:
Neurocysticercus, causative agent - Cysticercus cellulosus (larval stage of the pig chain);
hydratidous echinococcus of the liver, lungs, peritoneum, pathogen - Echinococcus granulosus (larval stage of the dog's tapeworm);
as an aid in the surgical treatment of alveolar echinococcosis, the causative agent is Echinococcus multilocularis.

- Hypersensitivity to albendazole, other components of the drug and other benzimidazole derivatives;
- retinal pathology;
- children under 3 years of age (for this dosage form);
Albendazole is used with caution for liver disfunction (it is necessary to regularly monitor liver function before and during treatment), inhibition of bone hematopoiesis, liver cirrhosis.

From the digestive system: liver disfunction with changes in functional liver tests (weak or moderate increase in the activity of "liver" transaminases), hepatitis, acute liver failure, epigastric pain, anorexia, constipation, diarrhea and dry mouth. nausea, vomiting.

If any of the side effects specified in the instructions are aggravated, or you notice any other side effects not specified in the instructions, please inform your doctor.

The dose of the drug is determined individually, depending on the type of invasion and body weight of the patient.
Children should, if possible, avoid using high doses of albendazole for a long time.
Standard dose in the treatment of invasion with roundworms for adults and children with a body weight of 60 kg or more - 400 mg per day once;
For giardiasis: 400 mg once a day for 3 days. Children with a body weight of less than 10 kg -200 mg once a day once for 5 days.
In neurocysticercosis and hydratidous echinoccusosis, patients with a body weight of 60 kg or more should take 400 mg 2 times a day, with a body weight of less than 60 kg - at the rate of 15 mg / kg of body weight per day in 2 doses; the maximum daily dose is 800 mg. The course of treatment for neurocysticercosis is 28-30 days (2 days before taking the drug and in the first week of administration, glucocorticosteroid drugs are taken), for echinococcus - 3 cycles of 28 days with a 14-day break between cycles.

Prescribing hepatoprotectors during treatment and in cases of toxic manifestations is ineffective, it is necessary to cancel the drug.
The doses and prescription regimen of the drug are the same as in hydratidous echinococcosis. The duration and course of treatment are determined by the patient's condition and tolerance of the drug.

Treatment: stomach rinsing, activated carbon use, symptomatic therapy.

Driving and other potentially dangerous activities that require increased concentration and speed of psychomotor reactions should be avoided, as the drug can cause dizziness and other side effects that may affect these abilities.

Film-coated tablets

Keep out of reach of children.

3 years.