Panangin 158 mg + 140 mg, 50 pcs.

Active ingredients:

potassium asparaginate (K + = 36.2 mg) 158 mg,

magnesium asparaginate anhydrous (Mg ++ = 11.8 mg) 140 mg;

Excipients:

anhydrous colloidal silica;

povidone;

magnesium stearate;

talc;

corn starch;

potato starch;

titanium dioxide;

macrogol 6000;

eudragit E

Pharmaceutical group:

 potassium and magnesium drug.

Pharmaceutical action:

 Panangin is a drug that affects metabolic processes. Source of potassium and magnesium ions.

Potassium and magnesium are intracellular cations that play a major role in the functioning of many enzymes, the interaction of macromolecules and intracellular structures, and in the mechanism of muscle contractility. The intra- and extracellular ratio of potassium, magnesium, calcium and sodium ions affects the contractility of the myocardium.

A low level of potassium and / or magnesium ions in the internal environment can have a proarrhythmogenic effect, predispose to the development of arterial hypertension, atherosclerosis of the coronary arteries and the occurrence of metabolic changes in the myocardium.

One of the most important physiological functions of potassium is to maintain the membrane potential of neurons, myocytes, and other excitable structures of myocardial tissue. An imbalance between the intra- and extracellular potassium content leads to a decrease in myocardial contractility, the occurrence of arrhythmias, tachycardia and increased toxicity of cardiac glycosides.

Magnesium is a cofactor for more than 300 enzymatic reactions of energy metabolism and synthesis of proteins and nucleic acids. Magnesium reduces contraction stress and heart rate, leading to a decrease in myocardial oxygen demand. Magnesium has an anti-ischemic effect on myocardial tissue. Decreased contractility of smooth muscle myocytes of arteriole walls, incl. coronary, leads to vasodilation and increased coronary blood flow.

The combination of potassium and magnesium ions in one preparation is justified by the fact that potassium deficiency in the body is often accompanied by a magnesium deficiency and requires simultaneous correction of the content of both ions in the body. With the simultaneous correction of the levels of these electrolytes, an additive effect is observed, in addition, potassium and magnesium reduce the toxicity of cardiac glycosides, without affecting their positive inotropic effect.

Heart failure, myocardial infarction, cardiac arrhythmias (mainly ventricular arrhythmias), additional therapy in the treatment of cardiac glycosides, hypokalemia, hypomagnesemia, insufficient intake of magnesium and potassium ions in the body with their deficiency in the diet.

Hypersensitivity, acute and chronic renal failure, Addison's disease, anuria, AV block II-III degree, cardiogenic shock, severe arterial hypotension, hyperkalemia, hypermagnesemia, severe myasthenia gravis, oliguria, hemolysis, amino acid metabolism disorder.

From the nervous system and sensory organs: increased fatigue, hyporeflexia, dizziness, fever, paresthesia.

From the side of the cardiovascular system and blood (hematopoiesis, hemostasis): lowering blood pressure, changes in ECG, impaired myocardial conduction and cardiac rhythm, phlebitis, vascular spasms, vasodilation, venous thrombosis.

From the respiratory system: dyspnea.

From the digestive tract: diarrhea, nausea, vomiting, dry mouth, rarely - abdominal pain, bleeding and ulceration of the intestines and gastric mucosa, perforation of the intestinal wall, flatulence, ulcers of the esophagus and duodenal ulcer.

From the side of metabolism: hyperkalemia.

From the musculoskeletal system: muscle weakness.

From the side of the skin: itching, increased sweating.

It inhibits the absorption of oral forms of tetracycline, iron salts and sodium fluoride (a 3-hour break between doses is required).

Due to the presence of potassium in the drug, the risk of hyperkalemia increases (control of the level of potassium in the blood plasma is necessary) when combined with ACE inhibitors, beta-blockers, cyclosporine, potassium-sparing diuretics, heparin and NSAIDs, the inhibitory effect on intestinal motility is enhanced. With the development of hyperkalemia, a decrease in the effect of digitalis drugs is possible.

Due to the presence of magnesium in the preparation, the neuromuscular blockade increases when combined with antidepolarizing muscle relaxants, inhibition of the central nervous system - when combined with drugs for anesthesia.

Reduces the effectiveness of neomycin, polymyxin B, tetracycline and streptomycin. Calcium preparations reduce the effectiveness, and calcitriol increases the level of magnesium in the blood plasma.

Inside, after eating. the acidic environment of the stomach reduces its effectiveness.

Before use, you should consult your doctor.

The usual daily dose is 1-2 tablets 3 times a day. The maximum daily dose is 3 tablets 3 times a day.

The duration of the drug intake and the need for repeated courses are determined by the doctor.

Symptoms: impaired conduction (especially with previous pathology of the cardiac conduction system).

Treatment: intravenous administration of calcium chloride; if necessary, hemodialysis and peritoneal dialysis.

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