Product Overview
Structure
Active substance:
pancreatin
Excipients.
Note:
The amount of pancreatian in milligrams is indicated for a substance with protease activity of 250 IU / g
pharmachologic effect
Compensates the insufficiency of exocrine pancreatic function, has a proteolytic, amylolytic and lipolytic effect.
The enzymes that make up pancreatin (lipase, amylase, trypsin, chymotrypsin) help break down proteins to amino acids, fats to glycerol and fatty acids, starch to dextrins and monosaccharides.
Improves the functional state of the gastrointestinal tract, normalizes digestion processes.
Trypsin inhibits the stimulated secretion of the pancreas, providing an analgesic effect.
Pharmacokinetics
Pancreatic enzymes are released from the dosage form in the alkaline environment of the small intestine, because protected from the action of gastric juice by the membrane.
Indications
- Replacement therapy for exocrine pancreatic insufficiency: chronic pancreatitis, pancreatectomy, post-irradiation, dyspepsia, cystic fibrosis.
- Flatulence, diarrhea of ​​non-infectious genesis, Remkheld’s syndrome (gastrocardial syndrome).
- Violation of the assimilation of food (condition after resection of the stomach and small intestine); to improve the digestion of food in individuals with normal gastrointestinal tract function in case of nutrition errors (eating fatty foods, large amounts of food, irregular meals) and with masticatory function disorders, a sedentary lifestyle, and prolonged immobilization.
- Preparation for x-ray and ultrasound examination of the abdominal organs.
- Flatulence, diarrhea of ​​non-infectious genesis, Remkheld’s syndrome (gastrocardial syndrome).
- Violation of the assimilation of food (condition after resection of the stomach and small intestine); to improve the digestion of food in individuals with normal gastrointestinal tract function in case of nutrition errors (eating fatty foods, large amounts of food, irregular meals) and with masticatory function disorders, a sedentary lifestyle, and prolonged immobilization.
- Preparation for x-ray and ultrasound examination of the abdominal organs.
Contraindications
Hypersensitivity to the drug, acute pancreatitis, exacerbation of chronic pancreatitis, children under 6 years old.
The drug contains lactose monohydrate, so its use is not recommended for patients with rare hereditary diseases associated with galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome.
Carefully
With cystic fibrosis, the drug should be prescribed with caution, because the dose should be adequate to the quantity and quality of food consumed, the use of pancreatin in high doses is not recommended due to an increased risk of developing strictures (fibrotic colonopathy).
Criteria for an adequately selected dose: increase in body weight, normalization of stool (less than 3 times a day, normalization of consistency), reduction of bloating.
Use during pregnancy and during breastfeeding
The safety of pancreatin during pregnancy is not well understood. Use is possible in cases where the expected benefit to the mother outweighs the potential risk to the fetus.
Side effects
Allergic reactions. Rarely - diarrhea, constipation, a feeling of discomfort in the stomach, nausea (a causal relationship between the development of these reactions and the action of pancreatin has not been established, because these phenomena relate to symptoms of exocrine pancreatic insufficiency). With prolonged use in high doses, the development of hyperuricosuria, hyperuricemia is possible. With cystic fibrosis, if the required dose of pancreatin is exceeded, strictures (fibrotic colonopathy) may develop in the ileocecal section in the ascending colon.
When using pancreatin in high doses in children, perianal irritation and irritation of the oral mucosa are possible.
Overdose
Symptoms: hyperuricosuria, hyperuricemia. In children - constipation.
Interaction
With simultaneous use with antacids containing calcium carbonate and / or magnesium hydroxide, a decrease in the effectiveness of pancreatin is possible.
With simultaneous use, it is theoretically possible to reduce the clinical effectiveness of acarbose.
With the simultaneous use of iron preparations, a decrease in iron absorption is possible.
How to take, course of administration and dosage
Inside. The drug is taken during or after a meal, without chewing and drinking with an alkaline liquid (water, fruit juices).
The duration of treatment can vary from a few days (if the digestive process is disturbed due to errors in the diet) to several months or years (if constant replacement therapy is necessary).
The dose is determined individually depending on the degree of digestion. Adults usually take 2-4 tablets 3-6 times a day. The maximum daily dose is 16 tablets.
In children over 6 years of age, the drug is used as directed by a doctor. The dose is determined individually. Usually, 1 tablet is prescribed 3 times a day.
Special instructions
The dose of the drug should be adequate to the amount of enzymes necessary for the absorption of fats, taking into account the quality and quantity of food consumed.
With prolonged use, iron preparations are prescribed at the same time.
Impact on the ability to drive vehicles and mechanisms
Release form
Tablets
Storage conditions
In a dry place, at a temperature not exceeding 20 ° C
Shelf life
2 years