Product Overview
Structure
Active substances :
dinoprostone 0.5 mg;
colloidal silicon dioxide;
triacetin
pharmachologic effect
Prepidil - stimulating labor.
Stimulates smooth muscles, modulates the reaction of internal organs to various hormonal effects.
Increases blood supply to the cervix, contributes to its softening and opening.
Pharmacokinetics
After endocervical injection of the gel, C max is reached after 30–45 min, and then rapidly decreases.
Indications
Preparation of the cervix for childbirth.
Pregnancy and lactation
Any dose of the drug that causes a prolonged increase in uterine tone poses a certain risk to the embryo or fetus.
In experimental animal studies, prostaglandin E 2 causes an increase in skeletal abnormalities in rats and rabbits; embryotoxicity of dinoprostone in rats and rabbits has also been identified.
Prostaglandins are excreted in breast milk in very small quantities, regardless of the duration of delivery.
Contraindications
Hypersensitivity, the presence of anamnestic information about cesarean section, extensive surgical interventions on the uterus, difficult and / or traumatic births, 6 or more full-term pregnancies, mismatch of the size of the pelvis of the mother and head of the fetus, abnormal position of the fetus, previous distress of the fetus, opening of the fetal bladder, spotting during pregnancy from the genital tract of unspecified etiology, infection of the lower genital tract.
Side effects
Abnormal contractions of the uterus, vomiting and / or diarrhea, changes in fetal heart rate, fetal distress, reduced status of the newborn (Apgar score below 7).
Interaction
Enhances the toxotropic activity of oxytocin.
How to take, course of administration and dosage
The contents of the syringe (3 g of gel corresponds to 0.5 mg of dinoprostone) using the attached catheter is injected into the cervical canal (below the level of the internal pharynx). After the procedure, you must lie on your back for 10-15 minutes to minimize leakage of the gel.
If the desired result from the use of Prepidil is achieved, the recommended interval to the administration of iv iv oxytocin is 6-12 hours. If the response to the initial dose of Prepidil is not achieved, you can re-assign it. The recommended repeated dose is 0.5 mg, and the interval from the previous administration is 6 hours.
The need for an additional appointment and the interval should be determined by the doctor, based on the clinical situation. The maximum recommended dose for a 24-hour period is 1.5 mg.
Overdose
Treatment: symptomatic, in / in the introduction of beta-adrenergic agonists or rapid delivery.
Special instructions
Avoid introducing the gel into the extra-amniotic space (possible uterine hyperstimulation).
Release form
Endocervical Gel
