Proginova 2mg 21 pills

1 dragee contains:

Active substance:

estradiol valerate2 mg;

Auxiliary substances:

lactose monohydrate 46 - 250 mg;

corn starch 26 - 200 mg;

povidon 25,000 - 3 mg;

talc - 2.4 mg;

magnesium stearate - 0.15 mg;

crystalline sucrose 33 - 540 mg;

povidone 700000 - 0.323 mg;

macrogol 6000 - 3.719 mg;

calcium carbonate precipitated 14 - 572 mg;

talc - 7.104 mg;

glycerol 85% (mass/mass) - 0.205 mg;

titanium dioxide (E171, C.1.77891) - 0.411 mg;

indigocarmine (E132, C.1.73015) - 0.051 mg;

montaglycol wax - 0.075 mg.

Proginova contains estrogen - estradiol valerate, which in the human body turns into a natural 17β-estradiol. Against the background of taking Proginova, ovulation is not suppressed, and the production of hormones in the body itself practically does not change.

Estradiol replenishes estrogen deficiency in the female body after menopause and provides effective treatment of psycho-emotional and vegetative menopausal symptoms (such as hot flashes, increased sweating, sleep disorders, increased nervous excitability, irritability, palpitations, cardialgia, dizziness, headache, decreased libido, muscle and joint pain); involutions of the skin and mucous membranes, especially urinary mucosa of the urinary system (urinary incontinence, dryness and irritation of the vaginal mucosa, pain during sexual intercourse).

HRT with an adequate dose of estrogen, such as in Proginov, reduces bone resorption and delays or stops bone loss in postmenopause. Long-term use of hormone replacement therapy (HRT) has been shown to reduce the risk of peripheral bone fractures in women after menopause. With the abolition of HRT, the rate of bone mass reduction is comparable to those typical for the period immediately after menopause. It has not been proven that using ZHT, it is possible to restore bone mass to the premenopausal level.

HRT also has a beneficial effect on the collagen content in the skin, as well as on its density, and can also slow down the process of wrinkles.

HRT leads to a decrease in total cholesterol, low-density lipoprotein cholesterol (LDL) and an increase in high-density lipoprotein cholesterol (HDL), as well as an increase in triglycerides. The addition of gestagen can to some extent prevent the effect of estradiol on metabolism. In general, the metabolic effects of HRT are considered positive and are considered to be involved in reducing the risk of cardiovascular disease in postmenopausal women.

Women with an unremoved uterus, when using Proginova, an additional intake of gestagen for at least 10 days in each cycle is recommended. This reduces the risk of endometrial hyperplasia and the concomitant risk of adenocarcinoma in women of this group.

Hormone replacement therapy (HRT) for menopausal disorders, involutive changes in the skin and genitourinary tract, depressive states in the menopausal period, as well as symptoms of estrogen deficiency due to natural menopause or sterilization;

prevention of postmenopausal osteoporosis.

• pregnancy;
• lactation period;
• bleeding from the vagina of unclear origin;
• confirmed or suspected breast cancer;
• confirmed or suspected hormone-dependent precancerous diseases or hormone-dependent malignant tumors;
• liver tumors now or in the past (benign or malignant);
• severe liver diseases;
• acute arterial thrombosis or thromboembolism (such as myocardial infarction, stroke);
• deep vein thrombosis in the acute stage, thromboembolism now or in the past;
• high risk of venous and arterial thrombosis;
• pronounced hypertriglyceridemia;
• congenital lactase deficiency, sacchase/isomaltase, lactose intolerance, glucose-galactose malabsorption;
• children and adolescents under 18 years of age;
• hypersensitivity to the components of Proginov's drug.

In rare cases - headache, nausea, stomach dysfunction, roughening of the mammary glands, change in body weight, uterine bleeding, chloasma.

Inside, after eating, without chewing and drinking a small amount of liquid, 1 dragee daily for 21 days, then a break of 7 days.

If there is menstruation, Proginov should be taken on the 5th day of menstrual bleeding.

In any other case, immediate treatment recommended by a doctor is possible.

If the uterus is preserved, it is possible to additionally prescribe another hormone - progesterone. And a doctor's recommendation is necessary: whether to take dragees constantly (without interruptions) or with interruptions.

The time of Proginov's reception day does not matter. However, if the first dragee is taken at a certain time of the day, you should stick to this time when taking all subsequent pills.

Dragee