Pyrantel

Active substance:

Pyrantela pamoat 735 mg is equivalent to a pyrantel base of 250 mg.
Excipients:

Sorbinic acid, sucrose, xanthan gum, methylparahydroxybenzoate, propylparahydroxybenzoate, sorbitol 70% solution, polysorbate 80, chocolate flavor S 2761 (composition: propylene glycol, water, caramel dye, natural, identical natural and artificial aromatic substances), flavor

A broad-spectrum anthelmintic drug. Causes neuromuscular blockade of sensitive helminths. Active against Enterobius vermicularis, Ascaris lumbriocoides, Ancylostoma duodenale, Necator americanus, Trichostrongylus orientalis, Trichostrongylus colubriformis. It affects both mature and immature individuals of both sexes, does not affect larvae during migration.

Suction

After ingestion, the pyrantel is poorly absorbed from the gastrointestinal tract. After taking a single dose of 10 mg/kg of body weight, the plasma pyrantel concentration is 0.005-0.13 μg/ml for 1-3 hours.

Distribution

There is no data on the distribution of pyrantel in the body's tissues and biological fluids (theoretically, the absorption of the active substance is minimal), as well as on the possibility of releasing the active substance with breast milk.

Metabolism and excretion

Pyrantel absorbed into systemic blood flow is partially metabolized in the liver to N-methyl-1,3-propanediamin. 93% of the dose taken is excreted unchanged with feces, about 7% - with urine unchanged or as a metabolite.

• Askaridosis;
• ankylostomosis;
• necatorosis;
• enterobiosis;
• trichocephalus.

The use of the drug during pregnancy and lactation (breastfeeding) is possible only if the intended benefit to the mother exceeds the potential risk to the fetus or child.

• Hypersensitivity to pyrantel;
• myasthenia (treatment period).

Caution is prescribed for liver failure and children under 6 months old.

From the gastrointestinal tract and liver: nausea, vomiting, diarrhea, stomach pain are possible; rarely - increased liver transaminase activity.

From the CNS side: rarely - headache, dizziness, drowsiness, insomnia, weakness; in some cases - hearing impairment, hallucinations, confusion, paresthesia.

Others: skin rash, fever.

When used together with piperazine, Pyrantel acts antagonistically (this combination is not recommended). Increases the concentration of theophylline in plasma.

In ascariasis and enterobiosis, in mixed invasions with these helminths - inside, once, after breakfast at the rate of 10 mg/kg.

Adults and children over 12 years old - 750 mg, with a body weight of more than 75 kg - 1 g.

Children from 6 months to 2 years old - 125 mg, 2-6 years old - 250 mg, 6-12 years old - 500 mg. In order to avoid self-invasion, it is allowed to repeat the course 3 weeks after the first admission.

In ankylostomosis, combination of necathorosis with ascariasis or other combined helminthic lesions, it is prescribed for 3 days for 10 mg/kg/day or within 2 days - 20 mg/kg/day.

In isolated ascaridosis - 5 mg/kg once.

Currently, no cases of overdose have been reported. Symptomatic therapy is carried out if necessary.

Enterobiosis should treat all cohabitants at the same time. After treatment is completed, a feces test for parasite eggs should be carried out. There is no data on the impact on driving and maintenance of mechanical equipment.

In a dry, dark place at a temperature not exceeding 25 oC.
Keep out of reach of children.

3 years.
The drug cannot be used after the expiration date indicated on the package.