Teraflex Advance 250 mg + 100 mg + 200 mg 120 pcs.

Active ingredients: 

glucosamine sulfate - 250 mg; 

chondroitin sodium sulfate - 200 mg; 

ibuprofen 100 mg

Excipients: 

MCC - 30.78 mg; 

corn starch - 19.69 mg; 

pregelatinized starch - 17.47 mg; 

stearic acid - 11.59 mg; 

sodium carboxymethyl starch - 10 mg; 

crospovidone - 10 mg; 

magnesium stearate - 3 mg; 

silicon dioxide - 4.05 mg; 

povidone - 2,382 mg.

Teraflex Advance is a drug that stimulates the regeneration of cartilage tissue, with an anti-inflammatory effect.

Chondroitin Sulfate Sodium serves as an additional substrate for the formation of a healthy cartilage matrix.

Stimulates the formation of hyaluronon, the synthesis of proteoglycans and collagen type II, and also protects hyaluronon from enzymatic degradation (by suppressing the activity of hyaluronidase); maintains the viscosity of the synovial fluid, stimulates cartilage repair mechanisms and inhibits the activity of those enzymes (elastase, hyaluronidase) that break down cartilage. 

When treating osteoarthritis, it relieves symptoms and reduces the need for NSAIDs.

Glucosamine sulfate activates the synthesis of proteoglycans, hyaluronic, chondroitinsulfuric acids and other substances that make up the articular membranes, intra-articular fluid and cartilage tissue.

Ibuprofen is a propionic acid derivative and has analgesic, antipyretic and anti-inflammatory effects due to the indiscriminate blockade of COX-1 and COX-2.

Glucosamine sulfate and chondroitin sulfate contained in the preparation potentiate the analgesic effect of ibuprofen.

Contraindicated in pregnancy and lactation.

• Hypersensitivity to any of the ingredients that make up the drug;
• a history of hypersensitivity to acetylsalicylic acid or other NSAIDs;
• erosive and ulcerative diseases of the gastrointestinal tract (including peptic ulcer of the stomach and duodenum in the acute stage, Crohn's disease, ulcerative colitis);
• aspirin asthma;
• hemophilia and other blood clotting disorders (including hypocoagulation);
• hemorrhagic diathesis;
• gastrointestinal bleeding;
• intracranial hemorrhage;
• pregnancy;
• lactation period;
• children under 12 years of age.

When using Teraflex Advance , nausea, abdominal pain, flatulence, diarrhea, constipation, and allergic reactions are possible. These reactions disappear after drug withdrawal.

The possibility of developing adverse reactions associated with the ibuprofen present in the drug should be taken into account. When using ibuprofen drugs in higher doses than those contained in Teraflex Advan s, the following undesirable effects may occur.

From the gastrointestinal tract : NSAIDs gastropathy (abdominal pain, nausea, vomiting, heartburn, loss of appetite, diarrhea, flatulence, constipation; rarely - ulceration of the gastrointestinal mucosa, which in some cases is complicated by perforation and bleeding); irritation or dryness of the oral mucosa, pain in the mouth, ulceration of the gingival mucosa, aphthous stomatitis, pancreatitis.

From the hepatobiliary system: hepatitis.

From the respiratory system : shortness of breath, bronchospasm.

From the senses: hearing impairment (hearing loss, ringing or tinnitus), visual impairment (toxic damage to the optic nerve, blurred vision or double vision, scotoma, dry and irritated eyes, conjunctival edema and eyelids of allergic genesis).

From the side of the central nervous system and peripheral nervous system : headache, dizziness, insomnia, anxiety, nervousness and irritability, psychomotor agitation, drowsiness, depression, confusion, hallucinations; rarely - aseptic meningitis (more often in patients with autoimmune diseases).

From the CVS : heart failure, tachycardia, increased blood pressure.

From the urinary system: acute renal failure, allergic nephritis, nephrotic syndrome (edema), polyuria, cystitis.

Allergic reactions : skin rash (usually erythematous or urticaria), pruritus, Quincke's edema, anaphylactoid reactions, anaphylactic shock, bronchospasm or dyspnea, fever, exudative erythema multiforme (including Stevens-Johnson syndrome), toxic epidermal syndrome (epidermal toxicity) Lyell), eosinophilia, allergic rhinitis.

From the side of hematopoiesis : anemia (including hemolytic, aplastic), thrombocytopenia and thrombocytopenic purpura, agranulocytosis, leukopenia.

Laboratory indicators : bleeding time may increase, serum glucose concentration may decrease, creatinine clearance may decrease; hematocrit or hemoglobin may decrease; serum creatinine concentration may increase; the activity of hepatic transaminases may increase.

Inside with a little water.

Adults - 2 caps. 3 times a day after meals.

The duration of admission without consulting a doctor should not exceed 3 weeks.

Further use of the drug should be discussed with your doctor.

During long-term treatment, it is necessary to control the picture of peripheral blood and the functional state of the liver and kidneys.

When symptoms of gastropathy appear, careful monitoring is shown, including esophagogastroduodenoscopy, blood test with determination of hemoglobin, hematocrit, fecal occult blood test.

If it is necessary to take additional NSAIDs and analgesics at the same time, the doctor should take into account the presence of ibuprofen in the drug. If long-term use of additional NSAIDs is required, Teraflex should be used, which does not contain ibuprofen.

If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study.

During the treatment period, alcohol intake is not recommended.

Influence on the ability to drive vehicles and other mechanisms  requiring increased concentration of attention:

Patients should refrain from activities requiring increased attention, quick mental and motor reactions.

Capsules