Teturam, 150 mg, 50 pcs.

1 tablet contains:

teturam 150 mg.

Excipients :

potato starch,

stearic acid

aerosil.

Teturam inhibits acetaldehyde dehydrogenase, which is involved in the metabolism of ethanol; increases the concentration of acetaldehyde, which is a metabolite of ethanol and causing a number of unpleasant symptoms after its use ("flushing" of blood to the skin of the face, nausea, vomiting, feeling unwell, tachycardia, lowering blood pressure).

As a result, a conditioned reflex reaction of disgust for the taste and smell of ethanol occurs.

The duration of action of oral tablets is 48 hours. The use in the form of implants creates a constant concentration of the drug in the body.

Disulfiram-ethanol reactions can occur within 5–9 months after implantation. In the case of ethanol, lipids are mobilized, blood vessels expand and blood flow rises at the implantation site, resulting in increased disulfiram intake in the blood.

• Treatment and prevention of relapse of chronic alcoholism.
• As a detoxification agent for chronic nickel poisoning.

Absolute:

- Complicated diseases of the cardiovascular system.

- The organ of hearing (neuritis of the auditory nerve).

- The organ of vision (glaucoma, optic neuritis).

- Bronchial asthma.

- Emphysema.

- Pulmonary tuberculosis.

- Severe liver failure.

- Diseases of the blood-forming organs.

- Diabetes.

- Thyrotoxicosis.

- Epilepsy.

- Convulsive syndrome of any genesis.

- Mental illness.

- Exacerbation of peptic ulcer.

- Kidney disease.

- Malignant tumors.

- Polyneuritis of any etiology.

- Pregnancy.

- Increased individual sensitivity to the drug.

Relative:

- Cardiovascular diseases in the stage of compensation.

- Old age (over 60 years old).

- Peptic ulcer of the stomach and duodenum in remission.

- Residual effects after NMC.

- Previously transferred teturamic (antabuse) psychoses.

Due to the properties of teturam: metallic taste in the mouth, unpleasant odor in patients with colostomy (associated with carbon sulfide), rare cases of hepatitis, sometimes found in patients with nickel eczema, not suffering from alcoholism, polyneuritis of the lower extremities, optic neuritis, memory loss, confusion , asthenia, headaches, skin allergic manifestations.

Ethanol associated with the combination of teturams: cases of respiratory failure, cardiovascular collapse, rhythm disturbances, angina pectoris, sometimes myocardial infarction, neurological disorders, and cerebral edema have been described.

Complications with prolonged use: rarely psychoses resembling alcoholic, hepatitis, gastritis; in patients with cardiovascular diseases, cerebral vascular thrombosis is possible, therefore, with complaints of paresthesia in the limbs and face, the drug should be discontinued immediately; exacerbation of polyneuritis.

When taking doses of alcohol in excess of 50 - 80 ml of vodka while taking Teturam: severe disorders of the cardiovascular and respiratory systems, edema, convulsions develop. In this case, detoxification therapy is urgently carried out, analeptics are administered, symptomatic treatment is carried out.

Contraindicated combinations

Alcohol: intolerance reaction (flushing, erythema, vomiting, tachycardia). Avoid drinking alcohol and medicines containing alcohol.

Undesirable combinations

Isoniazid: impaired behavior and coordination.

Nitro-5-imidazoles (metronidazole, ordinazole, secnidazole, tinidazole): delirious disorders, confusion.
Phenytoin .: a significant and rapid increase in plasma phenytoin levels with toxic symptoms (suppression of its metabolism).
If combinations cannot be avoided, clinical observation and monitoring of drug concentrations in the plasma of entry and after treatment with teturam should be carried out.

Combinations requiring caution

Warfarin (and other oral anticoagulants): increased effect of oral anticoagulants and the risk of bleeding (decreased breakdown of warfarin in the liver). More frequent monitoring of warfarin concentration and dose adjustment of anticoagulants within 8 days after teturam withdrawal is recommended.

Theophylline: Teturam inhibits theophylline metabolism. As a result of this, the theophylline dose should be adjusted (reduced dosage), depending on the clinical symptoms and plasma concentration of the drug.

Benzodiazepines: teturam can potentiate the sedative effect of benzodiazepines by inhibiting their oxidative metabolism (especially chlordiazepoxide and diazepam). The dosage of benzodiazepine should be adjusted in accordance with the clinical manifestations.

Tricyclic antidepressants: it is possible to intensify the reaction of alcohol intolerance (especially if patients taking teturam take alcoholic beverages).

Treatment is prescribed after a thorough examination of the patient and warning of the consequences and complications. The drug is taken orally at 150-500 mg 2 times a day according to an individual scheme.

After 7-10 days, a teturamalcoholic test is carried out (20-30 ml of 40% vodka after taking 500 mg of the drug), with a weak reaction, the dose of alcohol is increased by 10-20 ml (the maximum dose of vodka is 100-120 ml).

The test is repeated after 1-2 days in the hospital and after 3-5 days on an outpatient basis, with dose adjustment of alcohol and / or the drug as necessary. In the future, you can use a maintenance dose of 150-200 mg per day for 1-3 years.

Symptoms: a combination of teturam-ethanol can cause depression of consciousness up to coma, cardiovascular collapse, neurological complications.

Treatment: symptomatic.

Patients should be warned about the danger of a reaction of intolerance to alcohol.

Teturams should be taken with caution in patients with renal failure or hypothyroidism, especially at the risk of a possible combination with alcohol.

Pills