Product Overview
Composition
1 coated tablet contains:
active substance:
thioctic acid - 600 mg;
Excipients:
microcrystalline cellulose,
lactose,
talc,
silica colloidal
hypromellose,
lactose monohydrate,
sodium carboxyl methyl cellulose,
talc,
simethicone
magnesium stearate,
macrogol 600,
sodium lauryl sulfate.
pharmachologic effect
Thiogamma has a hepatoprotective, hypoglycemic, detoxification, hypolipidemic, hypocholesterolemic effect.
Thioctic acid (alpha lipoic acid) - an endogenous antioxidant (binds free radicals), is formed in the body by oxidative decarboxylation of alpha ketoxylate.
As a coenzyme of mitochondrial multienzyme complexes, it participates in the oxidative decarboxylation of pyruvic acid and alpha-keto acids.
It helps to reduce the concentration of glucose in the blood and increase glycogen in the liver, as well as to overcome insulin resistance. By the nature of the biochemical action, it is close to B vitamins. Participates in the regulation of lipid and carbohydrate metabolism, stimulates cholesterol metabolism, and improves liver function. It has hepatoprotective, hypolipidemic, hypocholesterolemic, hypoglycemic effect. Improves trophic neurons. The use of the meglumine salt of thioctic acid in solutions for intravenous administration (having a neutral reaction) can reduce the severity of adverse reactions.
Pharmacokinetics
When taken orally, it is rapidly and completely absorbed from the gastrointestinal tract (ingestion reduces absorption). The time to reach maximum concentration is 40-60 minutes. Bioavailability is 30%.
It has the effect of "first passage" through the liver. The formation of metabolites occurs as a result of side chain oxidation and conjugation.
The volume of distribution is about 450 ml / kg. Thioctic acid and its metabolites are excreted by the kidneys (80-90%). The elimination half-life is 20-50 minutes. The total plasma clearance is 10-15 ml / min.
Indications
Diabetic polyneuropathy, alcoholic polyneuropathy.
Pregnancy and lactation
The drug Thiogamma is contraindicated in pregnancy. If necessary, use the drug during lactation should stop breastfeeding.
In experimental animal studies, no teratogenic effect of thioctic acid was detected. No similar human studies have been conducted.
There is no data on the excretion of thioctic acid with breast milk.
Contraindications
- Hypersensitivity to the components of the drug Tiogamma.
- Pregnancy breastfeeding period.
- Children's age (efficacy and safety of use not established).
Side effects
When administered, dyspepsia is possible, including nausea, vomiting.
Interaction
With the simultaneous use of Thiogamma enhances the action of insulin and oral hypoglycemic agents.
With simultaneous administration with ethanol, the therapeutic effectiveness of thioctic acid may decrease.
How to take, course of administration and dosage
Inside, 600 mg is prescribed once a day.
Tablets are taken without chewing, washed down with a small amount of liquid.
Overdose
Symptoms: nausea, vomiting, headache.
The treatment is symptomatic. There is no specific antidote.
Special instructions
Patients taking Tiogamma should refrain from drinking alcohol.
In patients with diabetes, constant monitoring of blood glucose concentration is necessary, especially at the initial stage of therapy.
In some cases, it is necessary to reduce the dose of insulin or an oral hypoglycemic drug in order to avoid the development of hypoglycemia.
Release form
Coated tablets
