Product Overview
Structure
In a single dose (0.1 ml) of the drug
Active substance :
alpha-glutamyl-tryptophan (Timogen sodium in terms of thymogen) 25 mcg.
Excipients:
sodium chloride 900 mcg,
benzalkonium chloride 10 mcg,
purified water to 0.1 ml.
pharmachologic effect
Pharmacotherapeutic group:
Immunostimulating agent.
ATX Code: L03AX.
Pharmacological properties:
Pharmacodynamics:
It has a regulatory effect on the reactions of cellular, humoral immunity and nonspecific resistance of the body.
Stimulates regeneration processes in the event of inhibition. Improves the course of cellular metabolism.
It enhances the expression of differentiation receptors on lymphocytes, normalizes the number of T-helpers, cytotoxic T-lymphocytes and their ratio in patients with various immunodeficiency states.
Pharmacokinetics:
The drug quickly enters the systemic circulation after its intranasal administration. Peptidase alpha-glutamyl-tryptophan is cleaved by L-glutamic acid and L-tryptophan, which are involved in peptide synthesis in the body.
Indications
- Prevention and complex therapy of acute and chronic viral and bacterial diseases of the upper respiratory tract.
- Prevention of depression of immunity, blood formation, regeneration processes in the post-traumatic and postoperative periods.
- Complex adjuvant therapy to correct secondary immunodeficiency in radiation therapy, chemotherapy and antibiotic therapy.
- Combined therapy of acute and chronic infectious and inflammatory diseases accompanied by a decrease in immunity.
Pregnancy and lactation
Due to insufficient clinical data, taking the drug during pregnancy and during breastfeeding is possible only as directed by a doctor if the intended benefit to the mother outweighs the potential risk to the fetus or baby.
Please consult your doctor before taking the drug.
Contraindications
Hypersensitivity to the components of the drug, children under 1 year old.
If necessary, please consult your doctor before taking the drug.
Side effects
Allergic rhinitis.
Consult a doctor if you have the mentioned side effect or other side effects not listed in the instructions.
Interaction
Increases the effectiveness of chemotherapeutic drugs (cytostatic, antibacterial drugs) and radiation therapy.
It is not recommended to use simultaneously with large doses of glucocorticosteroid drugs.
The immunosuppressive effect of large doses of these drugs eliminates the immunostimulating effect of alpha-glutamyl-tryptophan.
How to take, course of administration and dosage
Locally.
Hold the bottle with the thumb on the base, and the nozzle of the dosing device between the middle and index fingers. Insert the nozzle of the dosing device into the nasal passage in a vertical position. Press nozzle once.
The drug is administered intranasally (in the nose) in doses:
Adults: 1 dose (one injection) in each nasal passage 2 times a day for 10 days for therapeutic purposes or for 3-5 days for preventive purposes.
Children: from 1 year to 6 years, 1 dose in one nasal passage 1 time per day, from 7 to 14 years, 1 dose in each nasal passage 1 time per day. The drug is used for 10 days for therapeutic purposes or for 3-5 days for prophylactic purposes. A repeated course of Timogen is carried out no earlier than 1 month later.
Overdose
In case of an overdose, there is an abundant secretion of the secretion of the nasal mucosa, which stops after the drug is discontinued. No treatment required.
Special instructions
The drug has no action features at the first dose and when it is canceled. There are no features of the use of the drug in children and adults with chronic diseases.
Information on the possible effect of a medicinal product for medical use on the ability to drive vehicles, mechanisms:
Release form
Dosage nasal spray 25 μg / dose of 10 ml in a dark glass bottle or a polymer bottle.
A metering pump (100 μl) is installed in the bottle with a plastic case, nozzle and protective cap.
One bottle with instructions for use in a pack of cardboard.
The number of doses in the bottle is at least 80.
Storage conditions
Store at a temperature of 2 ° C to 8 ° C.
Keep out of the reach of children.
Shelf life
2 years 6 months. Do not use after the expiration date indicated on the package.
