Product Overview
Composition
Active substances:
levodop
carbidop.
pharmachologic effect
TIDOMET FORTE - antiparkinsonian.
Indications
Parkinson's disease treatment.
Contraindications
- severe impaired liver and kidney function, severe psychosis
- angle-closure glaucoma
- hypersensitivity to the drug Tidomet forte.
Interaction
With the simultaneous use of levodopa with beta-adrenostimulants, ditilin and drugs for inhalation anesthesia, an increased risk of developing heart rhythm disturbances is possible; with tricyclic antidepressants - a decrease in the bioavailability of levodopa; with diazepam, clozapine, phenytoin, clonidine, m-anticholinergics, antipsychotics (antipsychotics) - derivatives of butyrophenone, diphenylbutylpiperidine, thioxanthene, phenothiazine, as well as with pyridoxine, papaverine, reserpine, a decrease in protivoparkin is possible; with lithium preparations, the risk of developing dyskinesias and hallucinations increases; with methyldopa - aggravation of side effects.
With the simultaneous use of levodopa with MAO inhibitors (with the exception of MAO inhibitors of type B), circulatory disorders are possible (taking MAO inhibitors should be stopped after 2 weeks). This is due to the accumulation of dopamine and norepinephrine under the influence of levodopa, the inactivation of which is inhibited by MAO inhibitors, and a high likelihood of developing excitation, increased blood pressure, tachycardia, facial redness and dizziness.
In patients receiving levodopa, the use of tubocurarine increases the risk of a pronounced decrease in blood pressure.
Iron salts may decrease the bioavailability of levodoids and carbidopa; the clinical significance of this interaction is unknown.
Although metoclopramide increases the bioavailability of levodopa by accelerating gastric emptying, it can nevertheless adversely affect disease control due to its antagonism with dopamine receptors.
How to take, course of administration and dosage
Inside, 1/4 tablet (250 mg / 25 mg) 2-3 times / day. Then the dose is increased by 1/4 tablet every 2-3 days until the optimal effect. Usually the optimal effect is observed at a dose of 1-2 tablets (250 mg / 25 mg) per day.
The maximum daily dose is 1.5 g of levodopa and 150 mg of carbidopa (6 tablets 250 mg / 25 mg).
Release form
Pills
